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Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects

 Hyung‐Chul Pae  ;  Joo‐Hyun Kang  ;  Jae‐Kook Cha  ;  Jung‐Seok Lee  ;  Jeong‐Won Paik  ;  Ui‐Won Jung  ;  Seong‐Ho Choi 
 Journal of Biomedical Materials Research Part B - Applied Biomaterials, Vol.107(7) : 2254-2262, 2019 
Journal Title
 Journal of Biomedical Materials Research Part B - Applied Biomaterials 
Issue Date
3D structure ; biphasic calcium phosphate ; bone regeneration ; synthetic
The purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three-dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro-computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro-CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Joo Hyun(강주현)
Pae, Hyung-Chul(배형철) ORCID logo https://orcid.org/0000-0002-6365-3557
Paik, Jeong Won(백정원) ORCID logo https://orcid.org/0000-0002-5554-8503
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
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