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Bone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects

DC FieldValueLanguage
dc.contributor.author백정원-
dc.contributor.author이중석-
dc.contributor.author정의원-
dc.contributor.author차재국-
dc.contributor.author최성호-
dc.contributor.author강주현-
dc.contributor.author배형철-
dc.date.accessioned2019-10-28T02:08:37Z-
dc.date.available2019-10-28T02:08:37Z-
dc.date.issued2019-
dc.identifier.issn1552-4973-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171506-
dc.description.abstractThe purpose of this study is to evaluate the efficacy of bone regeneration and volume maintenance of the three-dimensional (3D) structured biphasic calcium phosphate (BCP) block with porous hexahedron channels in a rabbit calvarial model. In this work, four circular defects (diameter: 8 mm) in calvarium of rabbits were randomly assigned to (1) negative control (control), (2) 3D hexahedron channel structured BCP block, (3) deproteinized bovine bone mineral particle, and (4) deproteinized porcine bone mineral particle. Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Outcome measures included micro-computed tomography (CT) and histomorphometrical analysis. Results indicated that in micro-CT, BCP group showed the highest new bone volume with significant difference compared to control (p = 0.008) at 8 weeks. Histomorphometrically, total augmented area of BCP group was the highest with significant difference compared to control (p = 0.008) at 8 weeks. BCP group also maintained total volume of the original defect without collapsing. BCP block with 3D hexahedron channel structure seems to have favorable osteogenic and volume maintaining ability and highly porous structure might attribute to new bone formation. Further studies regarding the optimal internal structure and porosity of the BCP block bone substitute are needed.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons-
dc.relation.isPartOfJournal of Biomedical Materials Research Part B - Applied Biomaterials-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBone regeneration using three-dimensional hexahedron channel structured BCP block in rabbit calvarial defects-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontics (치주과학교실)-
dc.contributor.googleauthorHyung‐Chul Pae-
dc.contributor.googleauthorJoo‐Hyun Kang-
dc.contributor.googleauthorJae‐Kook Cha-
dc.contributor.googleauthorJung‐Seok Lee-
dc.contributor.googleauthorJeong‐Won Paik-
dc.contributor.googleauthorUi‐Won Jung-
dc.contributor.googleauthorSeong‐Ho Choi-
dc.identifier.doi10.1002/jbm.b.34317-
dc.contributor.localIdA01836-
dc.contributor.localIdA03185-
dc.contributor.localIdA03185-
dc.contributor.localIdA03692-
dc.contributor.localIdA03692-
dc.contributor.localIdA04004-
dc.contributor.localIdA04004-
dc.contributor.localIdA04081-
dc.contributor.localIdA04081-
dc.contributor.localIdA05080-
dc.contributor.localIdA05080-
dc.contributor.localIdA05596-
dc.contributor.localIdA05596-
dc.relation.journalcodeJ01267-
dc.identifier.eissn1552-4981-
dc.identifier.pmid30675991-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.b.34317-
dc.subject.keyword3D structure-
dc.subject.keywordbiphasic calcium phosphate-
dc.subject.keywordbone regeneration-
dc.subject.keywordsynthetic-
dc.contributor.alternativeNamePaik, Jeong Won-
dc.contributor.affiliatedAuthor백정원-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor정의원-
dc.contributor.affiliatedAuthor정의원-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor최성호-
dc.contributor.affiliatedAuthor최성호-
dc.contributor.affiliatedAuthor강주현-
dc.contributor.affiliatedAuthor강주현-
dc.contributor.affiliatedAuthor배형철-
dc.contributor.affiliatedAuthor배형철-
dc.citation.volume107-
dc.citation.number7-
dc.citation.startPage2254-
dc.citation.endPage2262-
dc.identifier.bibliographicCitationJournal of Biomedical Materials Research Part B - Applied Biomaterials, Vol.107(7) : 2254-2262, 2019-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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