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Lung Adenocarcinoma Invasiveness Risk in Pure Ground-Glass Opacity Lung Nodules Smaller than 2 츠

Authors
 Geun Dong Lee   ;  Chul Hwan Park   ;  Heae Surng Park  ;  Min Kwang Byun  ;  Ik Jae Lee  ;  Tae Hoon Kim  ;  Sungsoo Lee 
Citation
 Thoracic and Cardiovascular Surgeon, Vol.67(4) : 321-328, 2019 
Journal Title
 Thoracic and Cardiovascular Surgeon 
ISSN
 0171-6425 
Issue Date
2019
MeSH
Adenocarcinoma in Situ/diagnostic imaging ; Adenocarcinoma in Situ/pathology* ; Adenocarcinoma in Situ/surgery ; Adenocarcinoma of Lung/diagnostic imaging ; Adenocarcinoma of Lung/pathology* ; Adenocarcinoma of Lung/surgery ; Adenoma/diagnostic imaging ; Adenoma/pathology* ; Adenoma/surgery ; Adult ; Aged ; Biopsy ; Female ; Humans ; Hyperplasia ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology* ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Multiple Pulmonary Nodules/diagnostic imaging ; Multiple Pulmonary Nodules/pathology* ; Multiple Pulmonary Nodules/surgery ; Neoplasm Invasiveness ; Pneumonectomy ; Retrospective Studies ; Solitary Pulmonary Nodule/diagnostic imaging ; Solitary Pulmonary Nodule/pathology* ; Solitary Pulmonary Nodule/surgery ; Tomography, X-Ray Computed ; Tumor Burden
Abstract
BACKGROUND: We aimed to identify clinicopathologic characteristics and risk of invasiveness of lung adenocarcinoma in surgically resected pure ground-glass opacity lung nodules (GGNs) smaller than 2 cm. METHODS: Among 755 operations for lung cancer or tumors suspicious for lung cancer performed from 2012 to 2016, we retrospectively analyzed 44 surgically resected pure GGNs smaller than 2 cm in diameter on computed tomography (CT). RESULTS: The study group was composed of 36 patients including 11 men and 25 women with a median age of 59.5 years (range, 34-77). Median follow-up duration of pure GGNs was 6 months (range, 0-63). Median maximum diameter of pure GGNs was 8.5 mm (range, 4-19). Pure GGNs were resected by wedge resection, segmentectomy, or lobectomy in 27 (61.4%), 10 (22.7%), and 7 (15.9%) cases, respectively. Pathologic diagnosis was atypical adenomatous hyperplasia, adenocarcinoma in situ, minimally invasive adenocarcinoma (MIA), or invasive adenocarcinoma (IA) in 1 (2.3%), 18 (40.9%), 15 (34.1%), and 10 (22.7%) cases, respectively. The optimal cutoff value for CT-maximal diameter to predict MIA or IA was 9.1 mm. In multivariate analyses, maximal CT-maximal diameter of GGNs ≥10 mm (odds ratio, 24.050; 95% confidence interval, 2.6-221.908; p = 0.005) emerged as significant independent predictor for either MIA or IA. Estimated risks of MIA or IA were 37.2, 59.3, 78.2, and 89.8% at maximal GGN diameters of 5, 10, 15, and 20 mm, respectively. CONCLUSION: Pure GGNs were highly associated with lung adenocarcinoma in surgically resected cases, while estimated risk of GGNs invasiveness gradually increased as maximal diameter increased.
Full Text
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1612615
DOI
10.1055/s-0037-1612615
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-3598-2529
Park, Chul Hwan(박철환) ORCID logo https://orcid.org/0000-0002-0004-9475
Park, Heae Surng(박혜성)
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
Lee, Geun Dong(이근동)
Lee, Sung Soo(이성수) ORCID logo https://orcid.org/0000-0001-8998-9510
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171078
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