0 70

Cited 0 times in

Effect of polydiacetylene-based nanosomes on cell viability and endocytosis

Authors
 Kyu Ha Park1  ;  Minhee Ku  ;  Nara Yoon  ;  Dae Youn Hwang  ;  Jaebeom Lee  ;  Jaemoon Yang  ;  Sungbaek Seo 
Citation
 Nanotechnology, Vol.30(24) : 245101, 2019 
Journal Title
 Nanotechnology 
ISSN
 0957-4484 
Issue Date
2019
MeSH
Cell Line, Tumor ; Cell Survival/drug effects* ; Endocytosis/drug effects* ; Humans ; Liposomes/administration & dosage ; Liposomes/chemistry ; Nanoparticles/administration & dosage* ; Nanoparticles/chemistry ; Polyacetylene Polymer/administration & dosage* ; Polyacetylene Polymer/chemistry
Abstract
Polydiacetylene-based nanoparticles have been developed as nanocarriers for various bio-applications. However, how nanocarriers enter the cell environment and affect cell viability has not yet been considerably explored. In this study, polydiacetylene-based nanoliposomes (nanosomes) were electrostatically complexed with rhodamine fluorophores. Based on real-time cell imaging and cell viability assessment, the most highly polymerized nanosomes were found to be less toxic to cells. Moreover, it was revealed that the rhodamine/polydiacetylene nanosome complex dissociates at cell environment, the polydiacetylene nanosome penetrates into cells, as suggested by the fluorescence observed in confocal microscopy images.
Full Text
https://iopscience.iop.org/article/10.1088/1361-6528/ab0ccf
DOI
10.1088/1361-6528/ab0ccf
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Min Hee(구민희) ORCID logo https://orcid.org/0000-0002-1674-1474
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170948
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse