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Uterine Artery Embolization in Patients With Autoimmune Disease: A Matched Case-Control Study

Authors
 Kichang Han  ;  Man-Deuk Kim  ;  Wonseon Shin  ;  Jason Jungsik Song  ;  Joon Ho Kwon  ;  Gyoung Min Kim  ;  Jong Yun Won 
Citation
 American Journal of Roentgenology, Vol.212(5) : 1148-1153, 2019 
Journal Title
 American Journal of Roentgenology 
ISSN
 0361-803X 
Issue Date
2019
Keywords
autoimmune disease ; deep venous thrombosis ; infection ; uterine artery embolization
Abstract
OBJECTIVE: The purpose of this study is to investigate the safety of uterine artery embolization (UAE) for symptomatic leiomyomas in patients with autoimmune disease. MATERIALS AND METHODS: Of 1183 patients who underwent UAE for symptomatic leiomyomas, nine patients (mean age, 42.6 years; range, 34-49 years) with autoimmune disease were included in this study. An age- and disease-matched control group (n = 8) was randomly generated from our patient registry to compare the effectiveness and safety of UAE in patients with autoimmune disease. Volume reduction rates of the uterus and dominant leiomyoma and the change in C-reactive protein (CRP) levels before and after UAE were compared. RESULTS: Except for one patient who had Takayasu arteritis and indiscernible uterine arteries on angiogram, UAE was technically successful in both groups. All of the patients who underwent technically successful UAE experienced improvement or resolution of symptoms (16/16; 100%). Complete necrosis of dominant fibroids was achieved in all patients (16/16; 100%). Although there was no significant difference in the mean initial CRP level before UAE (0.4 ± 0.14 mg/L vs 1.06 ± 1.26 mg/L; p = 0.067), it was significantly higher in the autoimmune group 1 day after UAE (1.23 ± 0.6 mg/L vs 9.54 ± 6.63 mg/L; p = 0.001). There was no significant difference in the volume reduction rates of uterus and dominant leiomyoma. In the autoimmune group, there was one major adverse event that was not related to underlying disease. CONCLUSION: In patients with autoimmune disease, UAE could be considered for symptomatic leiomyomas, as long as the underlying disease is well controlled.
Full Text
https://www.ajronline.org/doi/full/10.2214/AJR.18.20432
DOI
10.2214/AJR.18.20432
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Joon Ho(권준호) ORCID logo https://orcid.org/0000-0002-6178-7252
Kim, Gyoung Min(김경민) ORCID logo https://orcid.org/0000-0001-6768-4396
Kim, Man Deuk(김만득) ORCID logo https://orcid.org/0000-0002-3575-5847
Song, Jason Jungsik(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Won, Jong Yun(원종윤) ORCID logo https://orcid.org/0000-0002-8237-5628
Han, Ki Chang(한기창) ORCID logo https://orcid.org/0000-0002-9701-9757
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170928
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