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Higher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals

Authors
 Jung-Hwan Kim  ;  Yong-Jae Lee  ;  Byoungjin Park 
Citation
 MEDICINE, Vol.98(17) : e15340, 2019 
Journal Title
MEDICINE
ISSN
 0025-7974 
Issue Date
2019
MeSH
Adult ; Age Factors ; Aged ; Asian Continental Ancestry Group ; Biomarkers ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Inflammation/epidemiology ; Inflammation Mediators/metabolism ; Leukocyte Count/statistics & numerical data ; Lipids/blood ; Male ; Middle Aged ; Monocytes/metabolism ; Prognosis ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Factors
Abstract
Thecardiovasculardisease(CVD) has been identified as a leading cause of premature mortality among middle-aged and elderlyindividualsglobally. Inflammation plays an important role in aging and age-related diseases, such as atherosclerosis and CVD.Whitebloodcell(WBC)countis an inexpensive, simple biomarker of systemic inflammations and includes severalcellsubtype counts, such as neutrophils, monocytes, lymphocytes, basophils, and eosinophils. However, which component of a WBCcounthas the ability to predict CVD remains controversial. The objective of this study was to assess the association betweenmonocytecounts and10 year-CVDriskamongcommunity-dwellingKoreanindividualsusing theFraminghamriskscore(FRS). We studied a total of 627 participants aged over 30 years who underwent routine health examinations. The mean age of the study population was 48.1 ± 11.7 years, and 56.9% were male. In the multiple regression analysis, the independent contribution ofmonocytecounttoFramingham10-yearCVDriskwas 0.217 ± 0.092 (P = .018) after adjusting for confounding variables. We found that of the various WBCs,monocytecountis an independent predictor of CVDrisk. Further larger-scale prospective cohort studies are warranted to determine these associations in the future.
Files in This Item:
T201902241.pdf Download
DOI
10.1097/MD.0000000000015340
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung-Hwan(김정환)
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170415
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