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Higher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals

Authors
 Jung-Hwan Kim  ;  Yong-Jae Lee  ;  Byoungjin Park 
Citation
 MEDICINE, Vol.98(17) : e15340, 2019 
Journal Title
 MEDICINE 
ISSN
 0025-7974 
Issue Date
2019
MeSH
Adult ; Age Factors ; Aged ; Asian Continental Ancestry Group ; Biomarkers ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Inflammation/epidemiology ; Inflammation Mediators/metabolism ; Leukocyte Count/statistics & numerical data ; Lipids/blood ; Male ; Middle Aged ; Monocytes/metabolism ; Prognosis ; Prospective Studies ; Republic of Korea/epidemiology ; Risk Factors
Abstract
The cardiovascular disease (CVD) has been identified as a leading cause of premature mortality among middle-aged and elderly individuals globally. Inflammation plays an important role in aging and age-related diseases, such as atherosclerosis and CVD. White blood cell(WBC) count is an inexpensive, simple biomarker of systemic inflammations and includes several cell subtype counts, such as neutrophils, monocytes, lymphocytes, basophils, and eosinophils. However, which component of a WBC count has the ability to predict CVD remains controversial. The objective of this study was to assess the association between monocyte counts and 10 year-CVD risk among community-dwelling Korean individuals using the Framingham risk score (FRS). We studied a total of 627 participants aged over 30 years who underwent routine health examinations. The mean age of the study population was 48.1 ± 11.7 years, and 56.9% were male. In the multiple regression analysis, the independent contribution of monocyte count to Framingham 10-year CVD risk was 0.217 ± 0.092 (P = .018) after adjusting for confounding variables. We found that of the various WBCs, monocyte countis an independent predictor of CVD risk. Further larger-scale prospective cohort studies are warranted to determine these associations in the future.
Files in This Item:
T201902241.pdf Download
DOI
10.1097/MD.0000000000015340
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung-Hwan(김정환)
Park, Byoung Jin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170415
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