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Higher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals

DC FieldValueLanguage
dc.contributor.author김정환-
dc.contributor.author박병진-
dc.contributor.author이용제-
dc.date.accessioned2019-07-23T07:00:06Z-
dc.date.available2019-07-23T07:00:06Z-
dc.date.issued2019-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170415-
dc.description.abstractThe cardiovascular disease (CVD) has been identified as a leading cause of premature mortality among middle-aged and elderly individuals globally. Inflammation plays an important role in aging and age-related diseases, such as atherosclerosis and CVD. White blood cell(WBC) count is an inexpensive, simple biomarker of systemic inflammations and includes several cell subtype counts, such as neutrophils, monocytes, lymphocytes, basophils, and eosinophils. However, which component of a WBC count has the ability to predict CVD remains controversial. The objective of this study was to assess the association between monocyte counts and 10 year-CVD risk among community-dwelling Korean individuals using the Framingham risk score (FRS). We studied a total of 627 participants aged over 30 years who underwent routine health examinations. The mean age of the study population was 48.1 ± 11.7 years, and 56.9% were male. In the multiple regression analysis, the independent contribution of monocyte count to Framingham 10-year CVD risk was 0.217 ± 0.092 (P = .018) after adjusting for confounding variables. We found that of the various WBCs, monocyte countis an independent predictor of CVD risk. Further larger-scale prospective cohort studies are warranted to determine these associations in the future.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHBiomarkers-
dc.subject.MESHBlood Glucose-
dc.subject.MESHBlood Pressure-
dc.subject.MESHBody Mass Index-
dc.subject.MESHCardiovascular Diseases/epidemiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation/epidemiology-
dc.subject.MESHInflammation Mediators/metabolism-
dc.subject.MESHLeukocyte Count/statistics & numerical data-
dc.subject.MESHLipids/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMonocytes/metabolism-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.titleHigher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorJung-Hwan Kim-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorByoungjin Park-
dc.identifier.doi10.1097/MD.0000000000015340-
dc.contributor.localIdA05738-
dc.contributor.localIdA01477-
dc.contributor.localIdA01477-
dc.contributor.localIdA02982-
dc.contributor.localIdA02982-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid31027108-
dc.contributor.alternativeNameKim, Jung-Hwan-
dc.contributor.affiliatedAuthor김정환-
dc.contributor.affiliatedAuthor박병진-
dc.contributor.affiliatedAuthor박병진-
dc.contributor.affiliatedAuthor이용제-
dc.contributor.affiliatedAuthor이용제-
dc.citation.volume98-
dc.citation.number17-
dc.citation.startPagee15340-
dc.identifier.bibliographicCitationMEDICINE, Vol.98(17) : e15340, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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