Cited 25 times in
Higher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals
DC Field | Value | Language |
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dc.contributor.author | 김정환 | - |
dc.contributor.author | 박병진 | - |
dc.contributor.author | 이용제 | - |
dc.date.accessioned | 2019-07-23T07:00:06Z | - |
dc.date.available | 2019-07-23T07:00:06Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170415 | - |
dc.description.abstract | Thecardiovasculardisease(CVD) has been identified as a leading cause of premature mortality among middle-aged and elderlyindividualsglobally. Inflammation plays an important role in aging and age-related diseases, such as atherosclerosis and CVD.Whitebloodcell(WBC)countis an inexpensive, simple biomarker of systemic inflammations and includes severalcellsubtype counts, such as neutrophils, monocytes, lymphocytes, basophils, and eosinophils. However, which component of a WBCcounthas the ability to predict CVD remains controversial. The objective of this study was to assess the association betweenmonocytecounts and10 year-CVDriskamongcommunity-dwellingKoreanindividualsusing theFraminghamriskscore(FRS). We studied a total of 627 participants aged over 30 years who underwent routine health examinations. The mean age of the study population was 48.1 ± 11.7 years, and 56.9% were male. In the multiple regression analysis, the independent contribution ofmonocytecounttoFramingham10-yearCVDriskwas 0.217 ± 0.092 (P = .018) after adjusting for confounding variables. We found that of the various WBCs,monocytecountis an independent predictor of CVDrisk. Further larger-scale prospective cohort studies are warranted to determine these associations in the future. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Age Factors | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian Continental Ancestry Group | - |
dc.subject.MESH | Biomarkers | - |
dc.subject.MESH | Blood Glucose | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Cardiovascular Diseases/epidemiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammation/epidemiology | - |
dc.subject.MESH | Inflammation Mediators/metabolism | - |
dc.subject.MESH | Leukocyte Count/statistics & numerical data | - |
dc.subject.MESH | Lipids/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monocytes/metabolism | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Higher monocyte count with normal white blood cell count is positively associated with 10-year cardiovascular disease risk determined by Framingham risk score among community-dwelling Korean individuals | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Jung-Hwan Kim | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.identifier.doi | 10.1097/MD.0000000000015340 | - |
dc.contributor.localId | A05738 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A02982 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 31027108 | - |
dc.contributor.alternativeName | Kim, Jung-Hwan | - |
dc.contributor.affiliatedAuthor | 김정환 | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | e15340 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.98(17) : e15340, 2019 | - |
dc.identifier.rimsid | 62279 | - |
dc.type.rims | ART | - |
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