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Borderline high serum calcium levels are associated with arterial stiffness and 10-year cardiovascular disease risk determined by Framingham risk score

Authors
 Byoungjin Park  ;  Yong-Jae Lee 
Citation
 JOURNAL OF CLINICAL HYPERTENSION, Vol.21(5) : 668-673, 2019 
Journal Title
 JOURNAL OF CLINICAL HYPERTENSION 
ISSN
 1524-6175 
Issue Date
2019
Keywords
Framingham risk score ;  arterial stiffness ;  cardiovascular disease ; pulse wave velocity ;  serum calcium
Abstract
Recent epidemiological data indicate that the concentration of circulating calcium is related to cardiovascular disease (CVD) mortality. We determined whether serum calcium level is related to arterial stiffness and 10-year CVD risk calculated by Framingham risk score (FRS). We examined the association of normal-range serum calcium level with arterial stiffness and FRS in 565 Korean adults participating at the Health Promotion Center of Gangnam Severance Hospital between March 2016 and May 2017. High brachial-ankle pulse wave velocity (baPWV) was defined as >1460 cm/s, and high FRS was defined as ≥10 percent for 10-year CVD risk. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for high baPWV and high FRS were calculated using multiple logistic regression analysis after adjusting for confounding variables. The OR (95% CI) for high baPWV was 3.91 (1.15-7.36) per 1 mg/dL increment of serum calcium after adjusting for age, sex, body mass index, smoking status, exercise regularity, alcohol consumption, mean blood pressure, fasting plasma glucose, triglyceride, HDL-cholesterol, C-reactive protein, γ-glutamyltransferase, uric acid level, phosphate level, potassium level, and presence of hypertension, diabetes and dyslipidemia medications (P = 0.024). A positive association between serum calcium level and high FRS was also observed after adjusting for the same covariables (OR, 3.54 [95% CI, 1.01-12.44], P = 0.048). Serum calcium level was independently and positively associated with baPWV and 10-year CVD risk estimates. Early detection of higher serum calcium level may be important for the assessment of arterial stiffness and future risk of a cardiovascular event.
Files in This Item:
T201902228.pdf Download
DOI
10.1111/jch.13532
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Park, Byoung Jin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170406
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