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Associations of systemic inflammation with frontotemporal functional network connectivity and out-degree social-network size in community- dwelling older adults

Authors
 Minji Bang  ;  Junsol Kim  ;  Suk Kyoon An  ;  Yoosik Youm  ;  Jeanyung Chey  ;  Hyeon Chang Kim  ;  Kyungmee Park  ;  Kee Namkoong  ;  Eun Lee 
Citation
 BRAIN BEHAVIOR AND IMMUNITY, Vol.79 : 309-313, 2019 
Journal Title
 BRAIN BEHAVIOR AND IMMUNITY 
ISSN
 0889-1591 
Issue Date
2019
Keywords
Aging ; C-reactive protein ; Frontotemporal ; Functional network connectivity ; Out-degree ; Social network ; Systemic inflammation
Abstract
Increasing evidence suggests that systemic inflammation adversely affects social experiences and behaviors of older adults by changing the functional state of the brain. In this study, we investigated the relationships among systemic inflammation, functional network connectivity(FNC) of the whole brain, and social-network size using complete social-network data of olderadults residing in a Korean village. Sixty-one participants were recruited from the Korean Social Life, Health, and Aging Project (KSHAP). Participants underwent a resting-state functional magnetic resonance imaging scan. High sensitivity C-reactive protein (hs-CRP) levels were measured as an inflammation marker. In-degree and out-degree network sizes were calculated based on the total number of intimate social relationships per participant. We demonstrated that hs-CRP levels were associated with decreased frontotemporal FNC. Stronger frontotemporal FNC was significantly correlated with a larger out-degree networksize, suggesting that impaired frontotemporal communication in older adults decreases perceived social connectedness with other people. An exploratory mediation analysis supported the observation that increased systemic inflammation contributes to reduced out-degree social-network size among older adults by changing frontotemporal FNC. The present findings provide meaningful insight into the complex relationship between systemicinflammation and social quality of life.
Full Text
https://www.sciencedirect.com/science/article/pii/S0889159118305580
DOI
10.1016/j.bbi.2019.01.025
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
Park, Kyung Mee(박경미) ORCID logo https://orcid.org/0000-0002-2416-2683
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170269
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