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Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma

Authors
 GUOHUA ZHAO  ;  JUNG YOON BAE2  ;  ZHENLONG ZHENG  ;  HAE SEOK PARK  ;  KEE YANG CHUNG  ;  MI RYUNG ROH  ;  ZHEHU JIN 
Citation
 ANTICANCER RESEARCH, Vol.39(4) : 1849-1857, 2019 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2019
MeSH
Antigens, Neoplasm/metabolism* ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism* ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism* ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Cyclin-Dependent Kinase Inhibitor p21/genetics ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism* ; Progression-Free Survival ; Signal Transduction ; Skin Neoplasms/genetics ; Skin Neoplasms/metabolism* ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Young Adult
Keywords
Melanoma-associated antigen A12 ; cutaneous squamous cell carcinoma ; molecular biomarker ; p21 ; recurrence
Abstract
BACKGROUND/AIM: Melanoma-associated antigen A12 (MAGEA12) has recently been reported as a repressor of tumor-suppressor genes. This study aimed to investigate the implications of MAGEA12 expression in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). MATERIALS AND METHODS: MAGEA12 and p21 expression were investigated in 15 samples of normal skin and 111 of cSCC tissues by immunohistochemistry. The biological functions of MAGEA12 in cSCC were also investigated both in vitro and in vivo. RESULTS: Expression of both MAGEA12 and p21 was significantly increased in cSCC. MAGEA12 expression showed a positive correlation, while p21 expression showed negative correlation with the recurrence-free survival of patients with cSCC. In addition, MAGEA12 knockdown significantly attenuated proliferative, migratory, invasive, and tumorigenic activities of cSCC cells and was negatively correlated with p21 expression both in vitro and in vivo. CONCLUSION: MAGEA12-mediated down-regulation of p21 may be involved in cSCC pathogenesis and MAGEA12 may serve as a molecular biomarker in cSCC.
Full Text
http://ar.iiarjournals.org/content/39/4/1849.long
DOI
10.21873/anticanres.13292
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Bae, Jung Yoon(배정윤) ORCID logo https://orcid.org/0000-0001-8342-6987
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170003
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