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Overexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma

DC Field Value Language
dc.contributor.author노미령-
dc.contributor.author배정윤-
dc.contributor.author정기양-
dc.date.accessioned2019-07-11T03:30:17Z-
dc.date.available2019-07-11T03:30:17Z-
dc.date.issued2019-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170003-
dc.description.abstractBACKGROUND/AIM: Melanoma-associated antigen A12 (MAGEA12) has recently been reported as a repressor of tumor-suppressor genes. This study aimed to investigate the implications of MAGEA12 expression in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). MATERIALS AND METHODS: MAGEA12 and p21 expression were investigated in 15 samples of normal skin and 111 of cSCC tissues by immunohistochemistry. The biological functions of MAGEA12 in cSCC were also investigated both in vitro and in vivo. RESULTS: Expression of both MAGEA12 and p21 was significantly increased in cSCC. MAGEA12 expression showed a positive correlation, while p21 expression showed negative correlation with the recurrence-free survival of patients with cSCC. In addition, MAGEA12 knockdown significantly attenuated proliferative, migratory, invasive, and tumorigenic activities of cSCC cells and was negatively correlated with p21 expression both in vitro and in vivo. CONCLUSION: MAGEA12-mediated down-regulation of p21 may be involved in cSCC pathogenesis and MAGEA12 may serve as a molecular biomarker in cSCC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfANTICANCER RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntigens, Neoplasm/metabolism*-
dc.subject.MESHBiomarkers, Tumor/genetics-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHCarcinoma, Squamous Cell/genetics-
dc.subject.MESHCarcinoma, Squamous Cell/metabolism*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/therapy-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement-
dc.subject.MESHCell Proliferation-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21/genetics-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Proteins/genetics-
dc.subject.MESHNeoplasm Proteins/metabolism*-
dc.subject.MESHProgression-Free Survival-
dc.subject.MESHSignal Transduction-
dc.subject.MESHSkin Neoplasms/genetics-
dc.subject.MESHSkin Neoplasms/metabolism*-
dc.subject.MESHSkin Neoplasms/pathology-
dc.subject.MESHSkin Neoplasms/therapy-
dc.subject.MESHYoung Adult-
dc.titleOverexpression and Implications of Melanoma-associated Antigen A12 in Pathogenesis of Human Cutaneous Squamous Cell Carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorGUOHUA ZHAO-
dc.contributor.googleauthorJUNG YOON BAE2-
dc.contributor.googleauthorZHENLONG ZHENG-
dc.contributor.googleauthorHAE SEOK PARK-
dc.contributor.googleauthorKEE YANG CHUNG-
dc.contributor.googleauthorMI RYUNG ROH-
dc.contributor.googleauthorZHEHU JIN-
dc.identifier.doi10.21873/anticanres.13292-
dc.contributor.localIdA01278-
dc.contributor.localIdA01805-
dc.contributor.localIdA03582-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid30952725-
dc.identifier.urlhttp://ar.iiarjournals.org/content/39/4/1849.long-
dc.subject.keywordMelanoma-associated antigen A12-
dc.subject.keywordcutaneous squamous cell carcinoma-
dc.subject.keywordmolecular biomarker-
dc.subject.keywordp21-
dc.subject.keywordrecurrence-
dc.contributor.alternativeNameRoh, Mi Ryung-
dc.contributor.affiliatedAuthor노미령-
dc.contributor.affiliatedAuthor배정윤-
dc.contributor.affiliatedAuthor정기양-
dc.citation.volume39-
dc.citation.number4-
dc.citation.startPage1849-
dc.citation.endPage1857-
dc.identifier.bibliographicCitationANTICANCER RESEARCH, Vol.39(4) : 1849-1857, 2019-
dc.identifier.rimsid62331-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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