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Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear

 Jinsei Jung  ;  Jee Eun Yoo  ;  Young Ho Choe  ;  Sang Chul Park  ;  Hyun Jae Lee  ;  Hack June Lee  ;  Byunghwa Noh  ;  Sung Huhn Kim  ;  Gyeong-Yi Kang  ;  Kang-Mu Lee  ;  Sang Sun Yoon  ;  Dong Su Jang  ;  Joo-Heon Yoon  ;  Young-Min Hyun  ;  Jae Young Choi 
 CELL HOST & MICROBE, Vol.25(4) : 513-525, 2019 
Journal Title
Issue Date
DFNA9 ; LCCL ; cochlin ; hearing loss ; innate immunity ; inner ear ; pseudomonas
In the inner ear, endolymph fluid surrounds the organ of Corti, which is important for auditory function; notably, even slight environmental changes mediated by trauma or infection can have significant consequences. However, it is unclear how the immune response is modulated in these tissues. Here, we report the local immune surveillance role of cleaved cochlin LCCL (Limulus factor C, Cochlin, and Lgl1) during Pseudomonas aeruginosa infection in the cochlea. Upon infection, the LCCL domain is cleaved from cochlin and secreted into the perilymph. This cleaved fragment sequesters infiltrating bacteria in the scala tympani and subsequently recruits resident immune cells to eliminate the bacteria. Importantly, hearing loss in a cochlin knockout mouse model is remedied by treatment with a cochlin LCCL peptide. These findings suggest cleaved cochlin LCCL constitutes a critical factor in innate immunity and auditory function and may be a potential therapeutic target to treat chronic otitis media-induced hearing loss.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Huhn(김성헌)
Yoon, Sang Sun(윤상선) ORCID logo https://orcid.org/0000-0003-2979-365X
Yoon, Joo Heon(윤주헌)
Lee, Kang Mu(이강무) ORCID logo https://orcid.org/0000-0001-7414-5921
Jung, Jinsei(정진세) ORCID logo https://orcid.org/0000-0003-1906-6969
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0001-9493-3458
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
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