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Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients

Authors
 Kyoung Hoon Jeong  ;  Se Hoon Kim  ;  Yun Ho Choi  ;  Inja Cho  ;  Won-Joo Kim 
Citation
 EPILEPSY RESEARCH, Vol.147 : 58-61, 2018 
Journal Title
 EPILEPSY RESEARCH 
ISSN
 0920-1211 
Issue Date
2018
MeSH
Adolescent ; Adult ; Child ; Child, Preschool ; Epilepsy, Temporal Lobe/complications ; Epilepsy, Temporal Lobe/pathology* ; Female ; Hippocampus/pathology* ; Humans ; Male ; Middle Aged ; Neurons/metabolism* ; Phosphopyruvate Hydratase/metabolism ; Protein-Serine-Threonine Kinases/metabolism* ; Sclerosis/etiology ; Sclerosis/pathology ; Statistics, Nonparametric ; Up-Regulation/physiology* ; Young Adult
Keywords
Granule cell dispersion ; Hippocampal sclerosis ; Temporal lobe epilepsy ; WNK3
Abstract
Granule cell dispersion (GCD) is a common neuropathological feature of hippocampal sclerosis (HS) in patients with temporal lobe epilepsy (TLE). However, the underlying molecular mechanism of GCD formation remains unclear. The present study aimed to investigate the expressional changes of With No Lysine protein kinase subtype 3 (WNK3), a molecule upstream of cation-chloride cotransporters with reciprocal expression in sclerosed hippocampus of TLE patients. Using immunofluorescence staining, we analyzed WNK3 immunoreactivity in hippocampal specimens from histologically normal controls and TLE patients with HS. Our results showed that WNK3 expression was significantly increased in dispersed granule neurons in hippocampal tissues from patients with TLE compared with histologically normal hippocampus. These findings demonstrate a potential association between an increased expression of WNK3 and GCD formation during the chronic phase of epilepsy. Controlling WNK3 expression may thus be a novel therapeutic target in epileptogenesis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0920121118302559
DOI
10.1016/j.eplepsyres.2018.09.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169781
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