Cited 6 times in
Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김원주 | - |
dc.contributor.author | 정경훈 | - |
dc.contributor.author | 조인자 | - |
dc.date.accessioned | 2019-07-11T02:57:14Z | - |
dc.date.available | 2019-07-11T02:57:14Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0920-1211 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/169781 | - |
dc.description.abstract | Granule cell dispersion (GCD) is a common neuropathological feature of hippocampal sclerosis (HS) in patients with temporal lobe epilepsy (TLE). However, the underlying molecular mechanism of GCD formation remains unclear. The present study aimed to investigate the expressional changes of With No Lysine protein kinase subtype 3 (WNK3), a molecule upstream of cation-chloride cotransporters with reciprocal expression in sclerosed hippocampus of TLE patients. Using immunofluorescence staining, we analyzed WNK3 immunoreactivity in hippocampal specimens from histologically normal controls and TLE patients with HS. Our results showed that WNK3 expression was significantly increased in dispersed granule neurons in hippocampal tissues from patients with TLE compared with histologically normal hippocampus. These findings demonstrate a potential association between an increased expression of WNK3 and GCD formation during the chronic phase of epilepsy. Controlling WNK3 expression may thus be a novel therapeutic target in epileptogenesis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science Publishers | - |
dc.relation.isPartOf | EPILEPSY RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Epilepsy, Temporal Lobe/complications | - |
dc.subject.MESH | Epilepsy, Temporal Lobe/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hippocampus/pathology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neurons/metabolism* | - |
dc.subject.MESH | Phosphopyruvate Hydratase/metabolism | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/metabolism* | - |
dc.subject.MESH | Sclerosis/etiology | - |
dc.subject.MESH | Sclerosis/pathology | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.subject.MESH | Up-Regulation/physiology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Increased expression of WNK3 in dispersed granule cells in hippocampal sclerosis of mesial temporal lobe epilepsy patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Kyoung Hoon Jeong | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Yun Ho Choi | - |
dc.contributor.googleauthor | Inja Cho | - |
dc.contributor.googleauthor | Won-Joo Kim | - |
dc.identifier.doi | 10.1016/j.eplepsyres.2018.09.006 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00771 | - |
dc.relation.journalcode | J00796 | - |
dc.identifier.eissn | 1872-6844 | - |
dc.identifier.pmid | 30253317 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0920121118302559 | - |
dc.subject.keyword | Granule cell dispersion | - |
dc.subject.keyword | Hippocampal sclerosis | - |
dc.subject.keyword | Temporal lobe epilepsy | - |
dc.subject.keyword | WNK3 | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | 김세훈 | - |
dc.contributor.affiliatedAuthor | 김원주 | - |
dc.citation.volume | 147 | - |
dc.citation.startPage | 58 | - |
dc.citation.endPage | 61 | - |
dc.identifier.bibliographicCitation | EPILEPSY RESEARCH, Vol.147 : 58-61, 2018 | - |
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