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Gadoxetic acid enhanced magnetic resonance imaging for prediction of the postoperative prognosis of intrahepatic mass-forming cholangiocarcinoma

Authors
 Sungwon Kim  ;  Chansik An  ;  Kyunghwa Han  ;  Myeong-Jin Kim 
Citation
 Abdominal Radiology, Vol.44(1) : 110-121, 2019 
Journal Title
 Abdominal Radiology 
ISSN
 2366-004X 
Issue Date
2019
Keywords
Disodium gadoxetate ; Intrahepatic cholangiocarcinoma ; Magnetic resonance imaging ; Prognostic factors
Abstract
PURPOSE: To identify imaging markers that independently predict the post-operative outcome of intrahepatic mass-forming cholangiocarcinoma (IMCC) using gadoxetate disodium-enhanced magnetic resonance imaging (MRI). METHODS: Data from 54 patients who underwent pre-operative gadoxetate disodium-enhanced MRI and curative surgery for IMCC were retrospectively evaluated. The prognostic power of various imaging and pathological features reportedly associated with recurrence-free survival (RFS) and overall survival (OS) was analyzed using Cox regression models. A model combining imaging and pathological features was developed and its performance was evaluated using the Harrell C-index and Akaike information criterion. RESULTS: Capsule penetration (P = 0.016) and tumor size (P = 0.015) were independent markers for worse RFS, while capsule penetration (P = 0.012) and hepatic vein obstruction (HVO, P = 0.016) were independent markers for worse OS, respectively, in the imaging-based model. Capsule penetration was the only imaging marker identified in the combined prediction model of RFS, and the combined model showed a higher C-index and lower AIC value compared with the model based on pathological features alone. CONCLUSIONS: Capsule penetration and HVO on MRI are significantly worse imaging prognostic factors for post-operative outcomes in patients with IMCC. Incorporation of capsule penetration and HVO into a surgical staging system may improve prediction of the post-operative prognosis of IMCC.
Full Text
https://link.springer.com/article/10.1007%2Fs00261-018-1727-5
DOI
10.1007/s00261-018-1727-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
김성원(Kim, Sungwon) ORCID logo https://orcid.org/0000-0001-5455-6926
안찬식(An, Chansik) ORCID logo https://orcid.org/0000-0002-0484-6658
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167476
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