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Novel anti-biofouling bioactive calcium silicate-based cement containing 2-methacryloyloxyethyl phosphorylcholine

 Jae-Sung Kwon  ;  Myung-Jin Lee  ;  Ji-Young Kim  ;  Dohyun Kim  ;  Jeong-Hyun Ryu  ;  Sungil Jang  ;  Kwang-Mahn Kim  ;  Chung-Ju Hwang  ;  Sung-Hwan Choi 
 PLoS One, Vol.14(1) : e0211007, 2019 
Journal Title
 PLoS One 
Issue Date
Calcium silicate-based cements (CSCs) are commonly used for endodontic procedures; however, their antibacterial effects are limited. The objective of this study was to develop a 2-methacryloyloxyethyl phosphorylcholine (MPC)-incorporated CSC with improved antibacterial properties, while maintaining the original advantageous features of CSC. MPC was incorporated into a commercial CSC (Endocem MTA) at 0 wt% (control), 1.5%, 3.0 wt%, 5.0 wt%, 7.5 wt%, and 10 wt%. The setting time, compressive strength, water sorption, and glycerol contact angle were measured. Protein absorption was measured and bacterial adhesion on the surface was evaluated using Enterococcus faecalis. The bactericidal effect was examined by the disc diffusion test. Mineralization ability was assessed based on calcium ion deposition, as assessed by alizarin red staining, after immersion into Hank's balanced salt solution for 7 days. High concentrations of MPC in CSC (7.5 wt% and 10 wt%) increased the setting time, reduced compressive strength, and reduced wettability. MPC (3 wt%) had greater protein repellent and anti-biofouling effects than those of control and test materials (P < 0.001). However, no bactericidal effect was observed for any control or test materials. There was greater calcium ion deposition on the surface of MPC-supplemented CSC than on the control (P < 0.001). The addition of 3 wt% MPC polymer to CSC confers protein-repellent properties and reduced bacterial attachment, with the potential for improved mineralization.
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2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
권재성(Kwon, Jae-Sung) ORCID logo https://orcid.org/0000-0001-9803-7730
김광만(Kim, Kwang Mahn)
김도현(Kim, Dohyun) ORCID logo https://orcid.org/0000-0002-0772-6985
장성일(Jang, Sungil) ORCID logo https://orcid.org/0000-0001-6144-6899
최성환(Choi, Sung Hwan) ORCID logo https://orcid.org/0000-0002-1150-0268
황충주(Hwang, Chung Ju) ORCID logo https://orcid.org/0000-0003-3024-4551
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