441 479

Cited 0 times in

Combined effects of a chemically cross-linked porcine collagen membrane and highly soluble biphasic calcium phosphate on localized bone regeneration

 You-Kyoung Kim  ;  Yin-Zhe An  ;  Jae-Kook Cha  ;  Jung-Seok Lee  ;  Ui-Won Jung  ;  Seong-Ho Choi 
 Journal of the Korean Dental Association (대한치과의사협회지), Vol.56(12) : 667-685, 2018 
Journal Title
Journal of the Korean Dental Association(대한치과의사협회지)
Issue Date
Biodegradation ; Biphasic calcium phosphate ; Bone regeneration ; Bone substitute ; Collagen membrane
Objectives: Aim of this study was to evaluate bone regenerative efficacy of a chemically cross-linked porcine collagen membrane (CM) when used in combination with highly soluble biphasic calcium phosphate (BCP).
Materials and methods: Physiochemical properties of the experimental collagen membrane were analyzed. Four circumferential defects with diameter of 8 mm were created in each calvarium of New Zealand white rabbits (n = 10). Defects were randomly allocated to one of following 4 groups:

1) BCP-CM (BCP (20% hydroxyapatite/80% β-tricalcium phosphate) covered with the prepared collagen membrane), 2) BCP (only BCP used), 3) CM (only the prepared collagen membrane used), and 4) C (control; only blood clot). After 2 weeks (n = 5) and 8 weeks (n = 5), histologic and histomorphometric analyses were performed.

Results: The experimental collagen membrane exhibited dense and compact structure, relatively high tensile strength and lower degradability. Histologic analyses revealed that new bone increased rapidly at 2 weeks, while defect was preserved at 8 weeks. Histomorphometric analyses revealed that the new bone areas increased in the BCP-grafted groups over 8 weeks, with BCP-CM exhibiting greater total augmented area than that of BCP group both at 2 weeks (27.12±3.99 versus 21.97±2.27 ㎟) and 8 weeks (25.75±1.82 versus 22.48±1.10 ㎟) (P < 0.05).
Conclusions: The experimental collagen membrane successfully preserved localized defect for 8 weeks despite early rapid resorption of BCP. Within the study limitations, combined use of the chemically cross-linked porcine collagen membrane and highly soluble BCP aided localized bone regeneration.
Files in This Item:
T201804612.pdf Download
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, You-Kyoung(김유경)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.