395 413

Cited 0 times in

Combined effects of a chemically cross-linked porcine collagen membrane and highly soluble biphasic calcium phosphate on localized bone regeneration

DC Field Value Language
dc.contributor.author김유경-
dc.contributor.author이중석-
dc.contributor.author정의원-
dc.contributor.author차재국-
dc.contributor.author최성호-
dc.date.accessioned2019-01-15T17:00:19Z-
dc.date.available2019-01-15T17:00:19Z-
dc.date.issued2018-
dc.identifier.issn0376-4672-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166755-
dc.description.abstractObjectives: Aim of this study was to evaluate bone regenerative efficacy of a chemically cross-linked porcine collagen membrane (CM) when used in combination with highly soluble biphasic calcium phosphate (BCP). Materials and methods: Physiochemical properties of the experimental collagen membrane were analyzed. Four circumferential defects with diameter of 8 mm were created in each calvarium of New Zealand white rabbits (n = 10). Defects were randomly allocated to one of following 4 groups: 1) BCP-CM (BCP (20% hydroxyapatite/80% β-tricalcium phosphate) covered with the prepared collagen membrane), 2) BCP (only BCP used), 3) CM (only the prepared collagen membrane used), and 4) C (control; only blood clot). After 2 weeks (n = 5) and 8 weeks (n = 5), histologic and histomorphometric analyses were performed. Results: The experimental collagen membrane exhibited dense and compact structure, relatively high tensile strength and lower degradability. Histologic analyses revealed that new bone increased rapidly at 2 weeks, while defect was preserved at 8 weeks. Histomorphometric analyses revealed that the new bone areas increased in the BCP-grafted groups over 8 weeks, with BCP-CM exhibiting greater total augmented area than that of BCP group both at 2 weeks (27.12±3.99 versus 21.97±2.27 ㎟) and 8 weeks (25.75±1.82 versus 22.48±1.10 ㎟) (P < 0.05). Conclusions: The experimental collagen membrane successfully preserved localized defect for 8 weeks despite early rapid resorption of BCP. Within the study limitations, combined use of the chemically cross-linked porcine collagen membrane and highly soluble BCP aided localized bone regeneration.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한치과의사협회-
dc.relation.isPartOfJournal of the Korean Dental Association (대한치과의사협회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiodegradation-
dc.subject.MESHBiphasic calcium phosphate-
dc.subject.MESHBone regeneration-
dc.subject.MESHBone substitute-
dc.subject.MESHCollagen membrane-
dc.titleCombined effects of a chemically cross-linked porcine collagen membrane and highly soluble biphasic calcium phosphate on localized bone regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontics (치주과학교실)-
dc.contributor.googleauthorYou-Kyoung Kim-
dc.contributor.googleauthorYin-Zhe An-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorJung-Seok Lee-
dc.contributor.googleauthorUi-Won Jung-
dc.contributor.googleauthorSeong-Ho Choi-
dc.contributor.localIdA04729-
dc.contributor.localIdA03185-
dc.contributor.localIdA03185-
dc.contributor.localIdA03692-
dc.contributor.localIdA03692-
dc.contributor.localIdA04004-
dc.contributor.localIdA04004-
dc.contributor.localIdA04081-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ01820-
dc.contributor.alternativeNameKim, You-Kyoung-
dc.contributor.affiliatedAuthor김유경-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor이중석-
dc.contributor.affiliatedAuthor정의원-
dc.contributor.affiliatedAuthor정의원-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor최성호-
dc.contributor.affiliatedAuthor최성호-
dc.citation.volume56-
dc.citation.number12-
dc.citation.startPage667-
dc.citation.endPage685-
dc.identifier.bibliographicCitationJournal of the Korean Dental Association (대한치과의사협회지), Vol.56(12) : 667-685, 2018-
dc.identifier.rimsid58023-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.