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Inhibition of STAT5A promotes osteogenesis by DLX5 regulation

Authors
 Kyoung-Mi Lee  ;  Kwang Hwan Park  ;  Ji Suk Hwang  ;  Moses Lee  ;  Dong Suk Yoon  ;  Hyun Aae Ryu  ;  Ho Sun Jung  ;  Ki Won Park  ;  Jihyun Kim  ;  Sahng Wook Park  ;  Sung-Hwan Kim  ;  Yong-Min Chun  ;  Woo Jin Choi  ;  Jin Woo Lee 
Citation
 Cell Death & Disease, Vol.9(11) : 1136, 2018 
Journal Title
 Cell Death & Disease 
Issue Date
2018
Abstract
The regulation of osteogenesis is important for bone formation and fracture healing. Despite advances in understanding the molecular mechanisms of osteogenesis, crucial modulators in this process are not well-characterized. Here we demonstrate that suppression of signal transducer and activator of transcription 5A (STAT5A) activates distal-less homeobox 5 (DLX5) in human bone marrow-derived stromal cells (hBMSCs) and enhances osteogenesis in vitro and in vivo. We show that STAT5A negatively regulates expression of Dlx5 in vitro and that STAT5A deletion results in increased trabecular and cortical bone mass and bone mineral density in mice. Additionally, STAT5A deletion prevents age-related bone loss. In a murine fracture model, STAT5A deletion was found to significantly enhance bone remodeling by stimulating the formation of a fracture callus. Our findings indicate that STAT5A inhibition enhances bone formation by promoting osteogenesis of BMSCs.
Files in This Item:
T201804466.pdf.pdf Download
DOI
10.1038/s41419-018-1184-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
김성환(Kim, Sung Hwan) ORCID logo https://orcid.org/0000-0001-5743-6241
박광환(Park, Kwang Hwan) ORCID logo https://orcid.org/0000-0002-2110-0559
박상욱(Park, Sahng Wook) ORCID logo https://orcid.org/0000-0002-9594-7074
이경미(Lee, Kyoung Mi) ORCID logo https://orcid.org/0000-0002-9038-8162
이진우(Lee, Jin Woo) ORCID logo https://orcid.org/0000-0002-0293-9017
천용민(Chun, Yong Min) ORCID logo https://orcid.org/0000-0002-8147-6136
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166687
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