Cited 21 times in
Inhibition of STAT5A promotes osteogenesis by DLX5 regulation
DC Field | Value | Language |
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dc.contributor.author | 김성환 | - |
dc.contributor.author | 박광환 | - |
dc.contributor.author | 박상욱 | - |
dc.contributor.author | 이경미 | - |
dc.contributor.author | 이진우 | - |
dc.contributor.author | 천용민 | - |
dc.date.accessioned | 2019-01-15T16:51:43Z | - |
dc.date.available | 2019-01-15T16:51:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/166687 | - |
dc.description.abstract | The regulation of osteogenesis is important for bone formation and fracture healing. Despite advances in understanding the molecular mechanisms of osteogenesis, crucial modulators in this process are not well-characterized. Here we demonstrate that suppression of signal transducer and activator of transcription 5A (STAT5A) activates distal-less homeobox 5 (DLX5) in human bone marrow-derived stromal cells (hBMSCs) and enhances osteogenesis in vitro and in vivo. We show that STAT5A negatively regulates expression of Dlx5 in vitro and that STAT5A deletion results in increased trabecular and cortical bone mass and bone mineral density in mice. Additionally, STAT5A deletion prevents age-related bone loss. In a murine fracture model, STAT5A deletion was found to significantly enhance bone remodeling by stimulating the formation of a fracture callus. Our findings indicate that STAT5A inhibition enhances bone formation by promoting osteogenesis of BMSCs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | CELL DEATH & DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Inhibition of STAT5A promotes osteogenesis by DLX5 regulation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Kyoung-Mi Lee | - |
dc.contributor.googleauthor | Kwang Hwan Park | - |
dc.contributor.googleauthor | Ji Suk Hwang | - |
dc.contributor.googleauthor | Moses Lee | - |
dc.contributor.googleauthor | Dong Suk Yoon | - |
dc.contributor.googleauthor | Hyun Aae Ryu | - |
dc.contributor.googleauthor | Ho Sun Jung | - |
dc.contributor.googleauthor | Ki Won Park | - |
dc.contributor.googleauthor | Jihyun Kim | - |
dc.contributor.googleauthor | Sahng Wook Park | - |
dc.contributor.googleauthor | Sung-Hwan Kim | - |
dc.contributor.googleauthor | Yong-Min Chun | - |
dc.contributor.googleauthor | Woo Jin Choi | - |
dc.contributor.googleauthor | Jin Woo Lee | - |
dc.identifier.doi | 10.1038/s41419-018-1184-7 | - |
dc.contributor.localId | A00592 | - |
dc.contributor.localId | A01437 | - |
dc.contributor.localId | A01487 | - |
dc.contributor.localId | A04619 | - |
dc.contributor.localId | A03230 | - |
dc.contributor.localId | A04028 | - |
dc.relation.journalcode | J00482 | - |
dc.identifier.eissn | 2041-4889 | - |
dc.identifier.pmid | 30429452 | - |
dc.contributor.alternativeName | Kim, Sung Hwan | - |
dc.contributor.affiliatedAuthor | 김성환 | - |
dc.contributor.affiliatedAuthor | 박광환 | - |
dc.contributor.affiliatedAuthor | 박상욱 | - |
dc.contributor.affiliatedAuthor | 이경미 | - |
dc.contributor.affiliatedAuthor | 이진우 | - |
dc.contributor.affiliatedAuthor | 천용민 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1136 | - |
dc.identifier.bibliographicCitation | CELL DEATH & DISEASE, Vol.9(11) : 1136, 2018 | - |
dc.identifier.rimsid | 57956 | - |
dc.type.rims | ART | - |
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