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Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality

Authors
 Masaaki Sato  ;  Masako Kawano  ;  Kotaro Mizuta  ;  Tanvir Islam  ;  Min Goo Lee  ;  Yasunori Hayashi 
Citation
 eNeuro, Vol.4(3) : e0369-16.2017, 2017 
Journal Title
 eNeuro 
Issue Date
2017
Keywords
Shank ; autism ; hippocampus ; mice ; spatial memory ; virtual reality
Abstract
The demonstration of the ability of rodents to navigate in virtual reality (VR) has made it an important behavioral paradigm for studying spatially modulated neuronal activity in these animals. However, their behavior in such simulated environments remains poorly understood. Here, we show that encoding and retrieval of goal location memory in mice head-fixed in VR depends on the postsynaptic scaffolding protein Shank2 and the dorsal hippocampus. In our newly developed virtual cued goal location task, a head-fixed mouse moves from one end of a virtual linear track to seek rewards given at a target location along the track. The mouse needs to visually recognize the target location and stay there for a short period of time to receive the reward. Transient pharmacological blockade of fast glutamatergic synaptic transmission in the dorsal hippocampus dramatically and reversibly impaired performance of this task. Encoding and updating of virtual cued goal location memory was impaired in mice deficient in the postsynaptic scaffolding protein Shank2, a mouse model of autism that exhibits impaired spatial learning in a real environment. These results highlight the crucial roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in VR
Files in This Item:
T201706109.pdf Download
DOI
10.1523/ENEURO.0369-16.2017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/166112
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