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Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality

DC FieldValueLanguage
dc.contributor.author이민구-
dc.date.accessioned2018-12-12T03:44:33Z-
dc.date.available2018-12-12T03:44:33Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/166112-
dc.description.abstractThe demonstration of the ability of rodents to navigate in virtual reality (VR) has made it an important behavioral paradigm for studying spatially modulated neuronal activity in these animals. However, their behavior in such simulated environments remains poorly understood. Here, we show that encoding and retrieval of goal location memory in mice head-fixed in VR depends on the postsynaptic scaffolding protein Shank2 and the dorsal hippocampus. In our newly developed virtual cued goal location task, a head-fixed mouse moves from one end of a virtual linear track to seek rewards given at a target location along the track. The mouse needs to visually recognize the target location and stay there for a short period of time to receive the reward. Transient pharmacological blockade of fast glutamatergic synaptic transmission in the dorsal hippocampus dramatically and reversibly impaired performance of this task. Encoding and updating of virtual cued goal location memory was impaired in mice deficient in the postsynaptic scaffolding protein Shank2, a mouse model of autism that exhibits impaired spatial learning in a real environment. These results highlight the crucial roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in VR-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherSociety for Neuroscience-
dc.relation.isPartOfENEURO-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학교실)-
dc.contributor.googleauthorMasaaki Sato-
dc.contributor.googleauthorMasako Kawano-
dc.contributor.googleauthorKotaro Mizuta-
dc.contributor.googleauthorTanvir Islam-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorYasunori Hayashi-
dc.identifier.doi10.1523/ENEURO.0369-16.2017-
dc.contributor.localIdA02781-
dc.relation.journalcodeJ03548-
dc.identifier.eissn2373-2822-
dc.identifier.pmid28484738-
dc.subject.keywordShank-
dc.subject.keywordautism-
dc.subject.keywordhippocampus-
dc.subject.keywordmice-
dc.subject.keywordspatial memory-
dc.subject.keywordvirtual reality-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.affiliatedAuthor이민구-
dc.citation.volume4-
dc.citation.number3-
dc.citation.startPagee0369-16.2017-
dc.identifier.bibliographicCitationENEURO, Vol.4(3) : e0369-16.2017, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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