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한국 여성에서의 커피 섭취량과 혈중 알칼리인산분해효소와의 연관성: 2011년도 국민건강영양조사를 이용하여

Other Titles
 Relationship between Coffee Intake and Serum Alkaline Phosphatase in the Korean Women: Using the Korea National Health and Nutrition Examination Survey, 2011 
 최원준  ;  박신애  ;  정태하  ;  권유진  ;  심재용 
 Korean Journal of Family Practice (가정의학), Vol.6(5) : 421-425, 2016 
Journal Title
 Korean Journal of Family Practice (가정의학) 
Issue Date
Caffeine ; Methylxanthine ; Alkaline Phosphatase ; Anti-Inflammatory
Background: Caffeine is a compound of the methylxanthine class and emerging evidence supports its anti-inflammatory effect in addition to its bronchodilatory effect. Also, alkaline phosphatase (ALP) is related to the incidence and mortality of many diseases and its relation with C-reactive protein is being studied, suggesting its role as an inflammation marker. Thus, we examined the relationship between coffee consumption and serum ALP level. Methods: The study included 685 women of 8,518 people who participated in Korea National Health and Nutrition Examination Survey (KNHNES), 2011. We categorized daily coffee consumption as follows: less than one cup a day, one cup a day, two cups a day, and three cups a day. Multiple linear regression analyses were conducted to analyze the relationship between coffee consumption and serum ALP level. Results: For the four respective categories of daily coffee consumption, average serum ALP levels were 208.0 (±66.6), 203.0 (±57.8), 197.5 (±61.0), and 186.6 (±57.9) (IU/L). Serum ALP level significantly decreased in groups with higher coffee consumption. After adjusting for confounding factor, a significant inverse relationship between coffee consumption and serum ALP level was found in groups that consumed two or three cups a day. On the contrary, no significant relationship was seen in the group that consumed one cup a day (P=0.005, P=0.000, respectively). Conclusion: We found an inverse relationship between consumption of more than two cups of coffee a day and serum ALP level, suggesting a possible anti-inflammatory effect of moderate coffee consumption.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
최원준(Choi, Won Jun) ORCID logo https://orcid.org/0000-0002-8233-9272
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