한국 여성에서의 커피 섭취량과 혈중 알칼리인산분해효소와의 연관성: 2011년도 국민건강영양조사를 이용하여

Abstract

Background: Caffeine is a compound of the methylxanthine class and emerging evidence supports its anti-inflammatory effect in addition to its bronchodilatory effect. Also, alkaline phosphatase (ALP) is related to the incidence and mortality of many diseases and its relation with C-reactive protein is being studied, suggesting its role as an inflammation marker. Thus, we examined the relationship between coffee consumption and serum ALP level. Methods: The study included 685 women of 8,518 people who participated in Korea National Health and Nutrition Examination Survey (KNHNES), 2011. We categorized daily coffee consumption as follows: less than one cup a day, one cup a day, two cups a day, and three cups a day. Multiple linear regression analyses were conducted to analyze the relationship between coffee consumption and serum ALP level. Results: For the four respective categories of daily coffee consumption, average serum ALP levels were 208.0 (±66.6), 203.0 (±57.8), 197.5 (±61.0), and 186.6 (±57.9) (IU/L). Serum ALP level significantly decreased in groups with higher coffee consumption. After adjusting for confounding factor, a significant inverse relationship between coffee consumption and serum ALP level was found in groups that consumed two or three cups a day. On the contrary, no significant relationship was seen in the group that consumed one cup a day (P=0.005, P=0.000, respectively). Conclusion: We found an inverse relationship between consumption of more than two cups of coffee a day and serum ALP level, suggesting a possible anti-inflammatory effect of moderate coffee consumption.