24 36

Cited 1 times in

Relationship between Preoperative ¹⁸F-Fluorodeoxyglucose Uptake and Epidermal Growth Factor Receptor Status in Primary Colorectal Cancer

Authors
 Yun Jung Choi  ;  Min Jeong Kim  ;  Bong Hwa Lee  ;  Mi Jung Kwon  ;  Hee Sung Hwang 
Citation
 Yonsei Medical Journal, Vol.57(1) : 232-237, 2016 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2016
MeSH
Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/diagnostic imaging* ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Female ; Fluorodeoxyglucose F18/pharmacokinetics* ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Multimodal Imaging/methods* ; Neoplasm Staging ; Positron-Emission Tomography/methods* ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Radiography ; Radiopharmaceuticals/pharmacokinetics* ; Receptor, Epidermal Growth Factor/metabolism* ; Sensitivity and Specificity
Keywords
Colorectal cancer ; epidermal growth factor receptor ; ¹⁸F-fluorodeoxyglucose
Abstract
PURPOSE: Both ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake and epidermal growth factor receptor (EGFR) status are prognostic variables of colorectal cancer (CRC). The aim of this study was to investigate a possible association between ¹⁸F-FDG uptake on preoperative positron emission tomography/computed tomography (PET/CT) and EGFR status in primary CRC. MATERIALS AND METHODS: Records of 132 patients (66 men and 66 women; mean age=67.1±11.1 years) who underwent ¹⁸F-FDG PET/CT for CRC staging and subsequent bowel resection were reviewed. In primary lesions, ¹⁸F-FDG uptake was semiquantitatively evaluated in terms of maximum standardized uptake value (SUVmax), and EGFR status was determined by immunohistochemistry. Associations of clinicopathological parameters and EGFR status were analyzed by Pearson's chi-square test, multiple logistic regression, and receiver operating characteristic curves. RESULTS: Eighty-six patients (65.2%) showed EGFR expression. SUVmax was significantly lower in EGFR-negative tumors than in EGFR-expressing tumors (10.0±4.2 vs. 12.1±2.1; p=0.012). It was the only significant parameter correlated with EGFR expression (odds ratio=2.457; relative risk=2.013; p=0.038). At the SUVmax threshold of 7.5, the sensitivity and specificity for predicting EGFR expression were 84.9% and 40.4%, respectively (area under the curve=0.624; p=0.019). CONCLUSION: Preoperative ¹⁸F-FDG uptake is slightly correlated with EGFR status in primary CRC. Preoperative SUVmax of ¹⁸F-FDG may have a limited role in predicting EGFR expression in such tumors because of its poor specificity.
Files in This Item:
T999900216.pdf Download
DOI
10.3349/ymj.2016.57.1.232
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
최윤정(Choi, Yun-Jung)
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165665
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse