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Relationship between Preoperative ¹⁸F-Fluorodeoxyglucose Uptake and Epidermal Growth Factor Receptor Status in Primary Colorectal Cancer

DC FieldValueLanguage
dc.contributor.author최윤정-
dc.date.accessioned2018-11-20T11:47:04Z-
dc.date.available2018-11-20T11:47:04Z-
dc.date.issued2016-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165665-
dc.description.abstractPURPOSE: Both ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake and epidermal growth factor receptor (EGFR) status are prognostic variables of colorectal cancer (CRC). The aim of this study was to investigate a possible association between ¹⁸F-FDG uptake on preoperative positron emission tomography/computed tomography (PET/CT) and EGFR status in primary CRC. MATERIALS AND METHODS: Records of 132 patients (66 men and 66 women; mean age=67.1±11.1 years) who underwent ¹⁸F-FDG PET/CT for CRC staging and subsequent bowel resection were reviewed. In primary lesions, ¹⁸F-FDG uptake was semiquantitatively evaluated in terms of maximum standardized uptake value (SUVmax), and EGFR status was determined by immunohistochemistry. Associations of clinicopathological parameters and EGFR status were analyzed by Pearson's chi-square test, multiple logistic regression, and receiver operating characteristic curves. RESULTS: Eighty-six patients (65.2%) showed EGFR expression. SUVmax was significantly lower in EGFR-negative tumors than in EGFR-expressing tumors (10.0±4.2 vs. 12.1±2.1; p=0.012). It was the only significant parameter correlated with EGFR expression (odds ratio=2.457; relative risk=2.013; p=0.038). At the SUVmax threshold of 7.5, the sensitivity and specificity for predicting EGFR expression were 84.9% and 40.4%, respectively (area under the curve=0.624; p=0.019). CONCLUSION: Preoperative ¹⁸F-FDG uptake is slightly correlated with EGFR status in primary CRC. Preoperative SUVmax of ¹⁸F-FDG may have a limited role in predicting EGFR expression in such tumors because of its poor specificity.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYonsei Medical Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHColorectal Neoplasms/diagnostic imaging*-
dc.subject.MESHColorectal Neoplasms/metabolism-
dc.subject.MESHColorectal Neoplasms/pathology-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18/pharmacokinetics*-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultimodal Imaging/methods*-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPositron-Emission Tomography/methods*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHROC Curve-
dc.subject.MESHRadiography-
dc.subject.MESHRadiopharmaceuticals/pharmacokinetics*-
dc.subject.MESHReceptor, Epidermal Growth Factor/metabolism*-
dc.subject.MESHSensitivity and Specificity-
dc.titleRelationship between Preoperative ¹⁸F-Fluorodeoxyglucose Uptake and Epidermal Growth Factor Receptor Status in Primary Colorectal Cancer-
dc.typeArticle-
dc.contributor.college1. College of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorYun Jung Choi-
dc.contributor.googleauthorMin Jeong Kim-
dc.contributor.googleauthorBong Hwa Lee-
dc.contributor.googleauthorMi Jung Kwon-
dc.contributor.googleauthorHee Sung Hwang-
dc.identifier.doi10.3349/ymj.2016.57.1.232-
dc.contributor.localIdA05646-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid26632406-
dc.subject.keywordColorectal cancer-
dc.subject.keywordepidermal growth factor receptor-
dc.subject.keyword¹⁸F-fluorodeoxyglucose-
dc.contributor.alternativeNameChoi, Yun-Jung-
dc.contributor.affiliatedAuthor최윤정-
dc.citation.volume57-
dc.citation.number1-
dc.citation.startPage232-
dc.citation.endPage237-
dc.identifier.bibliographicCitationYonsei Medical Journal, Vol.57(1) : 232-237, 2016-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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