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Higher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals.

Authors
 Hyung-Jin Kim  ;  Mi-Ri Kim  ;  Jin-Kyung Park  ;  Yong-Jae Lee  ;  Byoungjin Park 
Citation
 Korean Journal of Family Medicine (가정의학회지), Vol.39(5) : 279-283, 2018 
Journal Title
 Korean Journal of Family Medicine (가정의학회지) 
ISSN
 2005-6443 
Issue Date
2018
Keywords
Ankle Brachial Index ; Cardiovascular Diseases ; Preclinical Peripheral Arterial Disease ; Serum Calcium Levels
Abstract
BACKGROUND: Epidemiological studies suggest that serum calcium levels correlate with cardiovascular events. An ankle-brachial index (ABI) between 0.9 and 1.00 is a surrogate estimation of preclinical peripheral arterial disease (PAD). Prior studies have shown that an ABI of 0.9-1.0 is also associated with endothelial dysfunction. Therefore, we sought to investigate the relationship between serum calcium levels and preclinical PAD in apparently healthy Korean individuals. METHODS: We evaluated the association between serum calcium levels and preclinical PAD in 596 participants (334 males, 262 females) in a health examination program. Preclinical PAD was defined by an ABI of 0.9-1.0. Multiple logistic regression analysis was used to determine whether the serum calcium level was an independent determinant of preclinical PAD. RESULTS: The overall prevalence of preclinical PAD was 14.3%. The mean age was 44.0±12.5 years in the non-PAD group and 48.3±11.4 years in the preclinical PAD group (P=0.001). After adjusting for age, gender, systolic blood pressure, fasting plasma glucose, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, g-glutamyltransferase, uric acid, hypertension medication, diabetes medication, and hyperlipidemia medication, the odds ratio (95% confidence intervals) for preclinical PAD was 2.28 (1.02-5.11) with a 1-mg/dL increase in the serum calcium. CONCLUSION: These findings suggest that increased serum calcium is independently and positively associated with preclinical PAD regardless of the presence of classic cardiovascular risk factors.
Files in This Item:
T201804032.pdf Download
DOI
10.4082/kjfm.17.0035
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
박병진(Park, Byoung Jin) ORCID logo https://orcid.org/0000-0003-1733-5301
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165455
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