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Higher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals.

DC FieldValueLanguage
dc.contributor.author박병진-
dc.contributor.author이용제-
dc.date.accessioned2018-11-16T16:54:18Z-
dc.date.available2018-11-16T16:54:18Z-
dc.date.issued2018-
dc.identifier.issn2005-6443-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/165455-
dc.description.abstractBACKGROUND: Epidemiological studies suggest that serum calcium levels correlate with cardiovascular events. An ankle-brachial index (ABI) between 0.9 and 1.00 is a surrogate estimation of preclinical peripheral arterial disease (PAD). Prior studies have shown that an ABI of 0.9-1.0 is also associated with endothelial dysfunction. Therefore, we sought to investigate the relationship between serum calcium levels and preclinical PAD in apparently healthy Korean individuals. METHODS: We evaluated the association between serum calcium levels and preclinical PAD in 596 participants (334 males, 262 females) in a health examination program. Preclinical PAD was defined by an ABI of 0.9-1.0. Multiple logistic regression analysis was used to determine whether the serum calcium level was an independent determinant of preclinical PAD. RESULTS: The overall prevalence of preclinical PAD was 14.3%. The mean age was 44.0±12.5 years in the non-PAD group and 48.3±11.4 years in the preclinical PAD group (P=0.001). After adjusting for age, gender, systolic blood pressure, fasting plasma glucose, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, g-glutamyltransferase, uric acid, hypertension medication, diabetes medication, and hyperlipidemia medication, the odds ratio (95% confidence intervals) for preclinical PAD was 2.28 (1.02-5.11) with a 1-mg/dL increase in the serum calcium. CONCLUSION: These findings suggest that increased serum calcium is independently and positively associated with preclinical PAD regardless of the presence of classic cardiovascular risk factors.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisher대한가정의학회-
dc.relation.isPartOfKorean Journal of Family Medicine (가정의학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHigher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorHyung-Jin Kim-
dc.contributor.googleauthorMi-Ri Kim-
dc.contributor.googleauthorJin-Kyung Park-
dc.contributor.googleauthorYong-Jae Lee-
dc.contributor.googleauthorByoungjin Park-
dc.identifier.doi10.4082/kjfm.17.0035-
dc.contributor.localIdA01477-
dc.contributor.localIdA01477-
dc.contributor.localIdA02982-
dc.relation.journalcodeJ02007-
dc.identifier.eissn2092-6715-
dc.identifier.pmid29972899-
dc.subject.keywordAnkle Brachial Index-
dc.subject.keywordCardiovascular Diseases-
dc.subject.keywordPreclinical Peripheral Arterial Disease-
dc.subject.keywordSerum Calcium Levels-
dc.contributor.alternativeNamePark, Byoung Jin-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.affiliatedAuthor박병진-
dc.contributor.affiliatedAuthor이용제-
dc.citation.volume39-
dc.citation.number5-
dc.citation.startPage279-
dc.citation.endPage283-
dc.identifier.bibliographicCitationKorean Journal of Family Medicine, Vol.39(5) : 279-283, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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