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Higher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals
DC Field | Value | Language |
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dc.contributor.author | 박병진 | - |
dc.contributor.author | 이용제 | - |
dc.date.accessioned | 2018-11-16T16:54:18Z | - |
dc.date.available | 2018-11-16T16:54:18Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2005-6443 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/165455 | - |
dc.description.abstract | BACKGROUND: Epidemiological studies suggest that serum calcium levels correlate with cardiovascular events. An ankle-brachial index (ABI) between 0.9 and 1.00 is a surrogate estimation of preclinical peripheral arterial disease (PAD). Prior studies have shown that an ABI of 0.9-1.0 is also associated with endothelial dysfunction. Therefore, we sought to investigate the relationship between serum calcium levels and preclinical PAD in apparently healthy Korean individuals. METHODS: We evaluated the association between serum calcium levels and preclinical PAD in 596 participants (334 males, 262 females) in a health examination program. Preclinical PAD was defined by an ABI of 0.9-1.0. Multiple logistic regression analysis was used to determine whether the serum calcium level was an independent determinant of preclinical PAD. RESULTS: The overall prevalence of preclinical PAD was 14.3%. The mean age was 44.0±12.5 years in the non-PAD group and 48.3±11.4 years in the preclinical PAD group (P=0.001). After adjusting for age, gender, systolic blood pressure, fasting plasma glucose, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, g-glutamyltransferase, uric acid, hypertension medication, diabetes medication, and hyperlipidemia medication, the odds ratio (95% confidence intervals) for preclinical PAD was 2.28 (1.02-5.11) with a 1-mg/dL increase in the serum calcium. CONCLUSION: These findings suggest that increased serum calcium is independently and positively associated with preclinical PAD regardless of the presence of classic cardiovascular risk factors. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한가정의학회 | - |
dc.relation.isPartOf | Korean Journal of Family Medicine (가정의학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Higher Serum Calcium Levels Are Associated with Preclinical Peripheral Arterial Disease among the Apparently Healthy Individuals | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Hyung-Jin Kim | - |
dc.contributor.googleauthor | Mi-Ri Kim | - |
dc.contributor.googleauthor | Jin-Kyung Park | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.identifier.doi | 10.4082/kjfm.17.0035 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A02982 | - |
dc.relation.journalcode | J02007 | - |
dc.identifier.eissn | 2092-6715 | - |
dc.identifier.pmid | 29972899 | - |
dc.subject.keyword | Ankle Brachial Index | - |
dc.subject.keyword | Cardiovascular Diseases | - |
dc.subject.keyword | Preclinical Peripheral Arterial Disease | - |
dc.subject.keyword | Serum Calcium Levels | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 279 | - |
dc.citation.endPage | 283 | - |
dc.identifier.bibliographicCitation | Korean Journal of Family Medicine (가정의학회지), Vol.39(5) : 279-283, 2018 | - |
dc.identifier.rimsid | 58919 | - |
dc.type.rims | ART | - |
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