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Lower-extremity magnetic resonance imaging in patients with hyperkalemic periodic paralysis carrying the SCN4A mutation T704M: 30-month follow-up of seven patients.

Authors
 Jeong, Ha-Neul  ;  Yi, Ji Sook  ;  Lee, Young Han  ;  Lee, Jung Hwan  ;  Shin, Ha Young  ;  Choi, Young-Chul a, Kim, Seung Min 
Citation
 NEUROMUSCULAR DISORDERS, Vol.28(10) : 837-845, 2018 
Journal Title
 NEUROMUSCULAR DISORDERS 
ISSN
 0960-8966 
Issue Date
2018
Keywords
Chronic progressive myopathy ; Fat quantification ; Hyperkalemic periodic paralysis ; Muscle MRI
Abstract
Hyperkalemic periodic paralysis (hyperKPP) is a muscle channelopathy characterized by recurrent paralytic attacks. Our previous study, in which we conducted whole-body muscle magnetic resonance imaging (MRI) in patients with hyperKPP, revealed muscle atrophy and fatty change in the lower extremity, especially in older persons. The aim of current study was to identify the progression of myopathy in hyperKPP patients had been assessed in the previous study. We performed lower-extremity muscle MRI in seven hyperKPP patients carrying the T704M mutation in the SCN4A gene at an interval of 30 months. Muscle atrophy, edematous change, fatty change, and fat fraction quantified using the Dixon technique were compared with the previous MRI findings. The lower-extremity MRI scan showed progressive muscle pathologic findings when compared with the previous study. Muscle atrophy, edematous change, and fatty change were prominent in the superficial posterior compartment of the lower leg. The follow-up lower-extremity muscle MRI findings provide evidence for chronic progressive myopathy and suggest the usefulness of MRI for assessing disease progression in patients with hyperKPP. This study is meaningful in terms of providing data showing the longitudinal changes of muscles in patients with periodic paralysis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0960896618301512
DOI
10.1016/j.nmd.2018.06.008
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Lee, Jung Hwan(이정환)
Jeong, Ha Neul(정하늘) ORCID logo https://orcid.org/0000-0002-5785-116X
Choi, Young Chul(최영철) ORCID logo https://orcid.org/0000-0001-5525-6861
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165370
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