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The Pattern of Striatal Dopamine Depletion as a Prognostic Marker in De Novo Parkinson Disease

Authors
 Seok Jong Chung  ;  Han Soo Yoo  ;  Hye Sun Lee  ;  Jungsu S. Oh  ;  Jae Seung Kim  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 Clinical Nuclear Medicine, Vol.43(11) : 787-792, 2018 
Journal Title
 Clinical Nuclear Medicine 
ISSN
 0363-9762 
Issue Date
2018
Keywords
Dopamine Depletion ; Dopamine Transporter ; Asymmetry ; Anteroposterior Gradient ; Parkinson Disease
Abstract
PURPOSE: To investigate whether the patterns of striatal dopamine depletion could provide prognostic information on the clinical profiles of early-stage Parkinson disease (PD). METHODS: Approximately 634 patients with drug-naive PD who underwent F-FP-CIT PET scans were followed up for at least 2 years. After quantifying dopamine transporter (DAT) availability in each striatal subregion, the patterns of striatal dopamine depletion of each patient were assessed based on (1) the degree of dopamine loss in the other striatal subregions compared to the posterior putamen (inter-subregional ratio [ISR]) and (2) the interhemispheric asymmetry of dopamine loss in the posterior putamen (asymmetry index [AI]). According to their patterns, we assessed the longitudinal changes in L-dopa-equivalent doses and L-dopa-induced dyskinesia (LID)-free times using the linear mixed model and Cox regression model, respectively. RESULTS: There was no significant correlation between the ISR and AI values (Pearson correlation coefficient, 0.150). The linear mixed model showed that higher AI values were associated with slower longitudinal increases in L-dopa-equivalent dose across time (P = 0.003), whereas ISR values were not (P = 0.154). The Cox regression model demonstrated that higher ISR values were associated with early development of LID (hazard ratio, 1.693; P = 0.010), whereas AI values were not (P = 0.269). CONCLUSIONS: The present study demonstrated that the pattern of anterior-to-posterior gradient and right-to-left asymmetry of striatal DAT availability predicted the development of LID and increasing doses of dopaminergic medications.
Full Text
https://insights.ovid.com/pubmed?pmid=30153150
DOI
10.1097/RLU.0000000000002251
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
유한수(Yoo, Han Soo) ORCID logo https://orcid.org/0000-0001-7846-6271
이필휴(Lee, Phil Hyu) ORCID logo https://orcid.org/0000-0001-9931-8462
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
정석종(Chung, Seok Jong) ORCID logo https://orcid.org/0000-0001-6086-3199
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165213
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