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β-Catenin activated hepatocellular adenoma: a report of three cases in Korea

Authors
 Gi Jeong Kim  ;  Jae Yeon Seok  ;  Hyungjin Rhee  ;  Jin-Young Choi  ;  Jin-Sub Choi  ;  Kyung Sik Kim  ;  Swan Thung  ;  Young Nyun Park 
Citation
 Gut and Liver, Vol.8(4) : 452-458, 2014 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2014
MeSH
Adult ; Carcinoma, Hepatocellular/metabolism* ; Female ; Humans ; Liver Neoplasms/metabolism* ; Male ; Middle Aged ; Republic of Korea ; Young Adult ; beta Catenin/metabolism*
Keywords
Adenoma ; Beta catenin ; Carcinoma ; Glutamine synthetase ; hepatocellular ; liver cell
Abstract
Hepatocellular adenoma (HCA) is an uncommon benign hepatic tumor, and the use of oral contraceptives is known to contribute to the development of HCA. Recently, a genotype and phenotype classification system for HCA was suggested, and malignant transformation to hepatocellular carcinoma (HCC) was shown to be strongly associated with activating mutations in β-catenin. Here, we report three cases of HCA in Korean patients: 7-cm, inflammatory and β-catenin-activated HCA with HCC transformation in a 46-year-old man; 13-cm, β-catenin-activated HCA with cytological atypia in a 23-year-old woman; and 10-cm, pigmented, inflammatory and β-catenin-activated HCA in a 36-year-old man. All cases exhibited the nuclear expression of β-catenin and diffuse cytoplasmic expression of glutamine synthetase upon immunohistochemical staining. All tumors were completely resected, and the patients were followed for 3 to 6 years with no evidence of local recurrence or metastasis.
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DOI
10.5009/gnl.2014.8.4.452
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
이형진(Rhee, Hyungjin) ORCID logo https://orcid.org/0000-0001-7759-4458
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163846
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