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PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation

 Heon Yung Gee  ;  Hyun Woo Park  ;  Kyung Hwan Kim  ;  Min Goo Lee 
 Journal of Medical Investigation, Vol.56(Suppl.) : 302-305, 2009 
Journal Title
 Journal of Medical Investigation 
Issue Date
Adaptor Proteins, Vesicular Transport/physiology* ; Animals ; Anions/metabolism ; Biological Transport/physiology ; Epithelial Cells/physiology* ; Humans ; PDZ Domains/physiology* ; Receptors, Vasoactive Intestinal Peptide/metabolism ; Tight Junctions/physiology
Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.
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1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
Park, Hyun Woo(박현우)
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Gee, Heon Yung(지헌영) ORCID logo https://orcid.org/0000-0002-8741-6177
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