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Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells

Authors
 Byeong Mo Kim  ;  Wonsuck Yoon  ;  Jung-Hyun Shim  ;  Haiyoung Jung  ;  Ji Hong Lim  ;  Hyun-Jung Choi  ;  MiRan Seo  ;  Tae Ho Lee  ;  Sang-Hyun Min 
Citation
 CURRENT PHARMACEUTICAL DESIGN, Vol.23(29) : 4259-4280, 2017 
Journal Title
 CURRENT PHARMACEUTICAL DESIGN 
ISSN
 1381-6128 
Issue Date
2017
MeSH
Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy* ; Protein Kinase Inhibitors/therapeutic use* ; Protein Kinases/radiation effects* ; Radiation, Ionizing ; Radiation-Sensitizing Agents/therapeutic use*
Keywords
Kinase ; cancer ; ionizing radiation ; protein ; radiation-sensitization strategies ; resistance ; therapeutic target
Abstract
Phosphorylation, the addition of a phosphate group to a molecule, is an effective way of regulating the biological properties of that molecule. Protein phosphorylation is a post-translational modification of proteins and affects cellular signaling transduction. Protein kinases induce phosphorylation by catalyzing the transfer of phosphate groups to serine, threonine, and tyrosine residues on protein substrates. Consistent with their roles in cancer, protein kinases have emerged as one of the most clinically useful target molecules in pharmacological cancer therapy. Intrinsic or acquired resistance of cancers against anti-cancer therapeutics, such as ionizing radiation, is a major obstacle for the effective treatment of many cancers. In this review, we describe key aspects of various kinases acting on proteins. We also discuss the roles of protein kinases in the pathophysiology and treatment of cancer. Because protein kinases correlate with radiation resistance in various types of cancer, we focus on several kinases responsible for radiation resistance and/or sensitivity and their therapeutic implications. Finally, we suggest some ongoing radiation-sensitization strategies using genetic loss and/or kinase inhibitors that can counteract radiation resistance-related protein kinases.
Full Text
http://www.eurekaselect.com/153006
DOI
10.2174/1381612823666170608084355
Appears in Collections:
5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
Seo, Mi Ran(서미란)
Choi, Hyun-Jung(최현정) ORCID logo https://orcid.org/0000-0003-3695-3420
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163589
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