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Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells

DC Field Value Language
dc.contributor.author최현정-
dc.contributor.author김병모-
dc.contributor.author서미란-
dc.date.accessioned2018-10-15T16:40:27Z-
dc.date.available2018-10-15T16:40:27Z-
dc.date.issued2017-
dc.identifier.issn1381-6128-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/163589-
dc.description.abstractPhosphorylation, the addition of a phosphate group to a molecule, is an effective way of regulating the biological properties of that molecule. Protein phosphorylation is a post-translational modification of proteins and affects cellular signaling transduction. Protein kinases induce phosphorylation by catalyzing the transfer of phosphate groups to serine, threonine, and tyrosine residues on protein substrates. Consistent with their roles in cancer, protein kinases have emerged as one of the most clinically useful target molecules in pharmacological cancer therapy. Intrinsic or acquired resistance of cancers against anti-cancer therapeutics, such as ionizing radiation, is a major obstacle for the effective treatment of many cancers. In this review, we describe key aspects of various kinases acting on proteins. We also discuss the roles of protein kinases in the pathophysiology and treatment of cancer. Because protein kinases correlate with radiation resistance in various types of cancer, we focus on several kinases responsible for radiation resistance and/or sensitivity and their therapeutic implications. Finally, we suggest some ongoing radiation-sensitization strategies using genetic loss and/or kinase inhibitors that can counteract radiation resistance-related protein kinases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBentham Science Publishers-
dc.relation.isPartOfCURRENT PHARMACEUTICAL DESIGN-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHHumans-
dc.subject.MESHNeoplasms/drug therapy-
dc.subject.MESHNeoplasms/radiotherapy*-
dc.subject.MESHProtein Kinase Inhibitors/therapeutic use*-
dc.subject.MESHProtein Kinases/radiation effects*-
dc.subject.MESHRadiation, Ionizing-
dc.subject.MESHRadiation-Sensitizing Agents/therapeutic use*-
dc.titleRole of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells-
dc.typeArticle-
dc.contributor.collegeResearch Institutes-
dc.contributor.departmentYonsei Integrative Research Institute for Cerebral & Cardiovascular Disease-
dc.contributor.googleauthorByeong Mo Kim-
dc.contributor.googleauthorWonsuck Yoon-
dc.contributor.googleauthorJung-Hyun Shim-
dc.contributor.googleauthorHaiyoung Jung-
dc.contributor.googleauthorJi Hong Lim-
dc.contributor.googleauthorHyun-Jung Choi-
dc.contributor.googleauthorMiRan Seo-
dc.contributor.googleauthorTae Ho Lee-
dc.contributor.googleauthorSang-Hyun Min-
dc.identifier.doi10.2174/1381612823666170608084355-
dc.contributor.localIdA04211-
dc.contributor.localIdA00497-
dc.contributor.localIdA01876-
dc.relation.journalcodeJ00681-
dc.identifier.eissn1873-4286-
dc.identifier.pmid28911303-
dc.identifier.urlhttp://www.eurekaselect.com/153006-
dc.subject.keywordKinase-
dc.subject.keywordcancer-
dc.subject.keywordionizing radiation-
dc.subject.keywordprotein-
dc.subject.keywordradiation-sensitization strategies-
dc.subject.keywordresistance-
dc.subject.keywordtherapeutic target-
dc.contributor.alternativeNameChoi, Hyun Jung-
dc.contributor.alternativeNameKim, Byeong Mo-
dc.contributor.alternativeNameSeo, Mi Ran-
dc.contributor.affiliatedAuthorChoi, Hyun-Jung-
dc.contributor.affiliatedAuthorKim, Byeong Mo-
dc.contributor.affiliatedAuthorSeo, Mi Ran-
dc.citation.volume23-
dc.citation.number29-
dc.citation.startPage4259-
dc.citation.endPage4280-
dc.identifier.bibliographicCitationCURRENT PHARMACEUTICAL DESIGN, Vol.23(29) : 4259-4280, 2017-
dc.identifier.rimsid58822-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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