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Breast Cancer Screening With Mammography Plus Ultrasonography or Magnetic Resonance Imaging in Women 50 Years or Younger at Diagnosis and Treated With Breast Conservation Therapy

 Nariya Cho  ;  Wonshik Han  ;  Boo-Kyung Han  ;  Min Sun Bae  ;  Eun Sook Ko  ;  Seok Jin Nam  ;  Eun Young Chae  ;  Jong Won Lee  ;  Sung Hun Kim  ;  Bong Joo Kang  ;  Byung Joo Song  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Seung Il Kim  ;  Sun Mi Kim  ;  Eunyoung Kang  ;  Yunhee Choi  ;  Hak Hee Kim  ;  Woo Kyung Moon 
 JAMA ONCOLOGY, Vol.3(11) : 1495-1502, 2017 
Journal Title
Issue Date
Adult ; Age Factors ; Biopsy ; Breast Neoplasms/diagnostic imaging* ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery* ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging* ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/surgery* ; Early Detection of Cancer/methods* ; Female ; Humans ; Magnetic Resonance Imaging* ; Mammography* ; Mastectomy, Segmental* ; Middle Aged ; Multimodal Imaging ; Neoplasm Staging ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Republic of Korea ; Risk Factors ; Time Factors ; Treatment Outcome ; Ultrasonography, Mammary*
Importance: Younger women (aged ≤50 years) who underwent breast conservation therapy may benefit from breast magnetic resonance imaging (MRI) screening as an adjunct to mammography. Objective: To prospectively determine the cancer yield and tumor characteristics of combined mammography with MRI or ultrasonography screening in women who underwent breast conservation therapy for breast cancers and who were 50 years or younger at initial diagnosis. Design, Setting, and Participants: This multicenter, prospective, nonrandomized study was conducted from December 1, 2010, to January 31, 2016, at 6 academic institutions. Seven hundred fifty-four women who were 50 years or younger at initial diagnosis and who had undergone breast conservation therapy for breast cancer were recruited to participate in the study. Reference standard was defined as a combination of pathology and 12-month follow-up. Interventions: Participants underwent 3 annual MRI screenings of the conserved and contralateral breasts in addition to mammography and ultrasonography, with independent readings. Main Outcomes and Measures: Cancer detection rate, sensitivity, specificity, interval cancer rate, and characteristics of detected cancers. Results: A total of 754 women underwent 2065 mammograms, ultrasonography, and MRI screenings. Seventeen cancers were diagnosed, and most of the detected cancers (13 of 17 [76%]) were stage 0 or stage 1. Overall cancer detection rate (8.2 vs 4.4 per 1000; P = .003) or sensitivity (100% vs 53%; P = .01) of mammography with MRI was higher than that of mammography alone. After the addition of ultrasonography, the cancer detection rate was higher than that by mammography alone (6.8 vs 4.4 per 1000; P = .03). The specificity of mammography with MRI or ultrasonography was lower than that by mammography alone (87% or 88% vs 96%; P < .001). No interval cancer was found. Conclusions and Relevance: After breast conservation therapy in women 50 years or younger, the addition of MRI to annual mammography screening improves detection of early-stage but biologically aggressive breast cancers at acceptable specificity. Results from this study can inform patient decision making on screening methods after breast conservation therapy.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
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