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Identification of Preoperative Magnetic Resonance Imaging Features Associated with Positive Resection Margins in Breast Cancer: A Retrospective Study

Authors
 Jung-Hyun Kang  ;  Ji Hyun Youk  ;  Jeong-Ah Kim  ;  Hye Mi Gweon  ;  Na Lae Eun  ;  Kyung Hee Ko  ;  Eun Ju Son 
Citation
 Korean Journal of Radiology, Vol.19(5) : 897-904, 2018 
Journal Title
 Korean Journal of Radiology 
ISSN
 1229-6929 
Issue Date
2018
Keywords
BI-RADS ; Breast cancer ; Breast-conserving surgery ; MRI ; Resection margin
Abstract
Objective: To determine which preoperative breast magnetic resonance imaging (MRI) findings and clinicopathologic features are associated with positive resection margins at the time of breast-conserving surgery (BCS) in patients with breast cancer. Materials and Methods: We reviewed preoperative breast MRI and clinicopathologic features of 120 patients (mean age, 53.3 years; age range, 27-79 years) with breast cancer who had undergone BCS in 2015. Tumor size on MRI, multifocality, patterns of enhancing lesions (mass without non-mass enhancement [NME] vs. NME with or without mass), mass characteristics (shape, margin, internal enhancement characteristics), NME (distribution, internal enhancement patterns), and breast parenchymal enhancement (BPE; weak, strong) were analyzed. We also evaluated age, tumor size, histology, lymphovascular invasion, T stage, N stage, and hormonal receptors. Univariate and multivariate logistic regression analyses were used to determine the correlation between clinicopathological features, MRI findings, and positive resection margins. Results: In univariate analysis, tumor size on MRI, multifocality, NME with or without mass, and segmental distribution of NME were correlated with positive resection margins. Among the clinicopathological factors, tumor size of the invasive breast cancer and in situ components were significantly correlated with a positive resection margin. Multivariate analysis revealed that NME with or without mass was an independent predictor of positive resection margins (odds ratio [OR] = 7.00; p < 0.001). Strong BPE was a weak predictor of positive resection margins (OR = 2.59; p = 0.076). Conclusion: Non-mass enhancement with or without mass is significantly associated with a positive resection margin in patients with breast cancer. In patients with NME, segmental distribution was significantly correlated with positive resection margins.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163453
Files in This Item:
T201802776.pdf Download
DOI
10.3348/kjr.2018.19.5.897
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
강졍현(Kang, Jung Hyun)
권혜미(Gweon, Hye Mi) ORCID logo https://orcid.org/0000-0002-3054-1532
김정아(Kim, Jeong Ah) ORCID logo https://orcid.org/0000-0003-4949-4913
손은주(Son, Eun Ju) ORCID logo https://orcid.org/0000-0002-7895-0335
육지현(Youk, Ji Hyun) ORCID logo https://orcid.org/0000-0002-7787-780X
은나래(Eun, Na Lae) ORCID logo https://orcid.org/0000-0002-7299-3051
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