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고콜레스테롤혈증 환자에서 식물성 스텔록이 혈청 지질농도에 미치는 영향.

Other Titles
 The Effect of Plant Sterol on Serum Cholesterol in Hypercholesterolemia Patients 
Authors
 신민정  ;  임세중  ;  장양수  ;  최동훈  ;  강석민  ;  조승연  ;  김성순  ;  김동기  ;  송기준  ;  정남식 
Citation
 Korean Circulation Journal (순환기), Vol.31(10) : 1027-1033, 2001 
Journal Title
 Korean Circulation Journal (순환기) 
ISSN
 1738-5520 
Issue Date
2001
Keywords
Phytosterols;Cholesterol;Lipoproteins, LDL cholesterol
Abstract
Background and Objectives:Phytosterols (Plant sterols) have been known to reduce serum cholesterol concentrations by inhibiting the absorption of both dietary and biliary cholesterol from the small intestines. In consideration of the lack of evaluation in Korea into the hypercholesterolemic effect of plant sterols, this study investigated the effect of plant sterol containing beverage on blood lipid profiles in hypercholesterolemic patients. Materials and Method:Forty-five hypercholesterolemic patients (fasting LDL-cholesterol\>130 mg/ dL) were fed either a placebo beverage for 4 weeks or a test beverage containing plant sterols for 8 weeks in a single-blind, randomized, cross-over study. The subjects were instructed to maintain the same amount of dietary fat and cholesterol intake during the study. After 4 weeks of plant sterols treatment, the dose of plant sterols was doubled (3.2 g/d) for subjects whose LDL-cholesterol reduction rate had not been reduced by 15%. Results:The study population consisted of 45 patients (15 males, 30 females, mean age 56) who completed the whole protocol. At baseline, the subjects’ mean dietary intake of saturated fat was 11.12 g, and cholesterol was 135.2 mg. After 8 weeks of treatment with plant sterols, serum concentrations of total cholesterol and LDL-cholesterol were significantly reduced by 4.38% (p=0.039), and 8.28% (p=0.036), respectively. However, the HDL-cholesterol and triglyceride levels/concentrations did not change significantly. Two-thirds of the subjects responded to treatment with plant sterols, and the mean reduction rates in LDL-cholesterol and total cholesterol levels/concentrations of those subjects were 14.1% and 9.2%, respectively. Conclusion:Our findings indicate that plant sterols significantly reduce serum total cholesterol and LDL-cholesterol concentrations and further suggest that plant sterols are also effective for those with low cholesterol intake.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/163367
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 3. College of Nursing (간호대학) > Dept. of Nursing (간호학과)
Yonsei Authors
강석민(Kang, Seok Min) ; 김성순(Kim, Sung Soon) ; 송기준(Song, Ki Jun) ; 임세중(Rim, Se Joong) ; 장양수(Jang, Yang Soo) ; 정남식(Chung, Nam Sik) ; 조승연(Cho, Seung Yun) ; 최동훈(Choi, Dong Hoon)
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