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Prognostic significance of preoperative CT findings in patients with advanced gastric cancer who underwent curative gastrectomy

Authors
 Chae Jung Park  ;  Nieun Seo  ;  Woo Jin Hyung  ;  Woong Sub Koom  ;  Hyo Song Kim  ;  Myeong-Jin Kim  ;  Joon Seok Lim 
Citation
 PLoS One, Vol.13(8) : e0202207, 2018 
Journal Title
 PLoS One 
Issue Date
2018
Abstract
BACKGROUND: Preoperative therapy has gained wide interest in advanced gastric cancer patients due to its potential advantages of improved disease control. Selection of high risk patients based on preoperative staging is crucial to choose the candidates for neoadjuvant therapy. METHODS: Our institutional review board approved this retrospective study and waived the requirement for patient consent. We searched 394 advanced gastric cancer patients (pT2-4) who underwent curative resection in 2010 without neoadjuvant therapies. Two abdominal radiologists independently reviewed the preoperative CT including tumor depth on CT (CT-tumor depth), which was categorized as follows: intramural, minimal extramural(<1mm), spiculated extramural(≥1mm) and nodular extramural infiltration. The impact of clinicoradiologic factors on disease recurrence and disease free survival (DFS) was evaluated. Recursive partitioning analysis was performed to suggest prediction models for recurrence. RESULTS: Of total 394 patients, 86 patients (21.8%) experienced recurrence. Spiculated (≥1mm) and nodular extramural tumor infiltration and CT size of 5-10cm were independent predictors of disease recurrence and significantly associated with worse DFS. Lymph node involvement on CT was not significantly associated with patient outcome. Among patients with same pT4a stage, the recurrence rate rises and DFS gets worse as the extramural tumor infiltration progresses (P < 0.001). The prediction model for recurrence revealed that size and CT-tumor depth were the two major discriminating factors. CONCLUSION: CT-tumor depth and size could be used as independent predictors for prognosis. Preoperative CT can be used for prognostic stratification to select high risk patients for whom neoadjuvant therapies might be considered.
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DOI
10.1371/journal.pone.0202207
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
금웅섭(Koom, Woong Sub) ORCID logo https://orcid.org/0000-0002-9435-7750
김명진(Kim, Myeong Jin) ORCID logo https://orcid.org/0000-0001-7949-5402
김효송(Kim, Hyo Song) ORCID logo https://orcid.org/0000-0002-0625-9828
박채정(Park, Chae Jung) ORCID logo https://orcid.org/0000-0002-5567-8658
서니은(Seo, Nieun) ORCID logo https://orcid.org/0000-0001-8745-6454
임준석(Lim, Joon Seok) ORCID logo https://orcid.org/0000-0002-0334-5042
형우진(Hyung, Woo Jin) ORCID logo https://orcid.org/0000-0002-8593-9214
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163314
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