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Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images

Authors
 Jisook Yi  ;  Young Han Lee  ;  Sang Kyum Kim  ;  Seung Hyun Kim  ;  Ho-Taek Song  ;  Kyoo-Ho Shin  ;  Jin-Suck Suh 
Citation
 Journal of Orthopaedic Science, Vol.23(3) : 570-577, 2018 
Journal Title
 Journal of Orthopaedic Science 
ISSN
 0949-2658 
Issue Date
2018
Abstract
BACKGROUND: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. METHODS: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. RESULTS: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. CONCLUSION: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.
Full Text
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0949265818300228
DOI
10.1016/j.jos.2018.01.006
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김상겸(Kim, Sang Kyum) ORCID logo https://orcid.org/0000-0003-0768-9923
김승현(Kim, Seung Hyun)
서진석(Suh, Jin Suck)
송호택(Song, Ho Taek) ORCID logo https://orcid.org/0000-0002-6655-2575
신규호(Shin, Kyoo Ho)
이영한(Lee, Young Han) ORCID logo https://orcid.org/0000-0002-5602-391X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162476
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