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Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images

DC FieldValueLanguage
dc.contributor.author김상겸-
dc.contributor.author김승현-
dc.contributor.author서진석-
dc.contributor.author송호택-
dc.contributor.author신규호-
dc.contributor.author이영한-
dc.date.accessioned2018-08-28T17:18:59Z-
dc.date.available2018-08-28T17:18:59Z-
dc.date.issued2018-
dc.identifier.issn0949-2658-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162476-
dc.description.abstractBACKGROUND: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. METHODS: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016. This study was approved by the institutional review board. Pre- and post-treatment size, histogram, and textural parameters of GCTBs were compared by the Wilcoxon signed-rank test. Pathological findings of five patients who underwent surgery after denosumab treatment were evaluated for assessment of treatment response. RESULTS: Relative to the baseline values, the tumor size had decreased, while the mean attenuation, standard deviation, entropy (all, P = 0.017), and skewness (P = 0.036) of the GCTBs had significantly increased post-treatment. Although the difference was statistically insignificant, the tumors also exhibited increased kurtosis, contrast, and inverse difference moment (P = 0.123, 0.327, and 0.575, respectively) post-treatment. Histologic findings revealed new bone formation and complete depletion or decrease in the number of osteoclast-like giant cells. CONCLUSION: The histogram and textural parameters of GCTBs changed significantly after denosumab treatment. Knowledge of the tendency towards increased mean attenuation and heterogeneity but increased local homogeneity in post-treatment CT histogram and textural features of GCTBs might aid in treatment planning and tumor response evaluation during denosumab treatment.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJournal of Orthopaedic Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleResponse evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJisook Yi-
dc.contributor.googleauthorYoung Han Lee-
dc.contributor.googleauthorSang Kyum Kim-
dc.contributor.googleauthorSeung Hyun Kim-
dc.contributor.googleauthorHo-Taek Song-
dc.contributor.googleauthorKyoo-Ho Shin-
dc.contributor.googleauthorJin-Suck Suh-
dc.identifier.doi10.1016/j.jos.2018.01.006-
dc.contributor.localIdA00520-
dc.contributor.localIdA00662-
dc.contributor.localIdA01916-
dc.contributor.localIdA02080-
dc.contributor.localIdA02086-
dc.contributor.localIdA02967-
dc.relation.journalcodeJ01671-
dc.identifier.eissn1436-2023-
dc.identifier.pmid29429890-
dc.identifier.urlhttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0949265818300228-
dc.contributor.alternativeNameKim, Sang Kyum-
dc.contributor.alternativeNameKim, Seung Hyun-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.alternativeNameShin, Kyoo Ho-
dc.contributor.alternativeNameLee, Young Han-
dc.contributor.affiliatedAuthorKim, Sang Kyum-
dc.contributor.affiliatedAuthorKim, Seung Hyun-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.contributor.affiliatedAuthorShin, Kyoo Ho-
dc.contributor.affiliatedAuthorLee, Young Han-
dc.citation.volume23-
dc.citation.number3-
dc.citation.startPage570-
dc.citation.endPage577-
dc.identifier.bibliographicCitationJournal of Orthopaedic Science, Vol.23(3) : 570-577, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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