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Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer

 Jisup Kim  ;  Sinae Kim  ;  Hye Sun Lee  ;  Wookyeom Yang  ;  Hanbyoul Cho  ;  Doo Byung Chay  ;  Seong Jin Cho  ;  Soonwon Hong  ;  Jae-Hoon Kim 
 Gynecologic Oncology, Vol.149(2) : 381-387, 2018 
Journal Title
 Gynecologic Oncology 
Issue Date
B7-H1 Antigen/*biosynthesis/immunology ; Endometrioid/*immunology Carcinoma ; Endometrial Neoplasms/*immunology ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Prognosis ; Programmed Cell Death 1 Receptor/*biosynthesis/immunology ; Retrospective Studies
Endometrial cancer ; Immunohistochemistry ; Prognostic factor ; Programmed cell death 1 ligand 1 ; Tumor microenvironments
OBJECTIVE: Monoclonal antibodies targeting programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) demonstrated promising clinical response. The predictive/prognostic value of PD-1/PD-L1 immunohistochemistry (IHC) has been evaluated in many cancer types. However, the prognostic value of PD-1/PD-L1 IHC has not been evaluated in endometrial cancer. METHODS: We conducted a retrospective study to quantify the IHC CD8, PD-1, and PD-L1 expressions in immune cells at center of tumor (CT), invasive margin (IM), and/or tumor cell in 183 primary endometrial cancer samples from a single cohort, followed by their reciprocal combinations, including compartmental differences, and correlated them with overall survival (OS) and progression-free survival (PFS). RESULTS: In repeated Cox multivariable models adjusted by clinicoimmunopathologic factors, high CT-PD-L1 was an independent adverse prognostic factor for PFS in all patients and in the microsatellite-stable subgroup. Immune marker ratios revealed independently shorter PFS for high CT-PD-L1/CT-CD8 and CT-PD-L1/CT-PD-1 ratios. Classification of endometrial cancer into four groups based on CT-CD8 and CT-PD-L1 revealed significantly different survival among groups. CONCLUSIONS: The high PD-L1/CD8 ratio and the high expression of PD-L1 on immune cells were independent poor prognostic factors for PFS in endometrial cancer, providing insights into the tumor microenvironment.
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1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Si Nae(김시내)
Kim, Jae Hoon(김재훈) ORCID logo https://orcid.org/0000-0001-6599-7065
Kim, Jisup(김지섭) ORCID logo https://orcid.org/0000-0002-0742-5517
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Hanbyoul(조한별) ORCID logo https://orcid.org/0000-0002-6177-1648
Chay, Doo Byung(채두병) ORCID logo https://orcid.org/0000-0002-0648-4021
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
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