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Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer

DC FieldValueLanguage
dc.contributor.author김시내-
dc.contributor.author김재훈-
dc.contributor.author이혜선-
dc.contributor.author조한별-
dc.contributor.author채두병-
dc.contributor.author홍순원-
dc.contributor.author김지섭-
dc.date.accessioned2018-08-28T17:14:32Z-
dc.date.available2018-08-28T17:14:32Z-
dc.date.issued2018-
dc.identifier.issn0090-8258-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162397-
dc.description.abstractOBJECTIVE: Monoclonal antibodies targeting programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) demonstrated promising clinical response. The predictive/prognostic value of PD-1/PD-L1 immunohistochemistry (IHC) has been evaluated in many cancer types. However, the prognostic value of PD-1/PD-L1 IHC has not been evaluated in endometrial cancer. METHODS: We conducted a retrospective study to quantify the IHC CD8, PD-1, and PD-L1 expressions in immune cells at center of tumor (CT), invasive margin (IM), and/or tumor cell in 183 primary endometrial cancer samples from a single cohort, followed by their reciprocal combinations, including compartmental differences, and correlated them with overall survival (OS) and progression-free survival (PFS). RESULTS: In repeated Cox multivariable models adjusted by clinicoimmunopathologic factors, high CT-PD-L1 was an independent adverse prognostic factor for PFS in all patients and in the microsatellite-stable subgroup. Immune marker ratios revealed independently shorter PFS for high CT-PD-L1/CT-CD8 and CT-PD-L1/CT-PD-1 ratios. Classification of endometrial cancer into four groups based on CT-CD8 and CT-PD-L1 revealed significantly different survival among groups. CONCLUSIONS: The high PD-L1/CD8 ratio and the high expression of PD-L1 on immune cells were independent poor prognostic factors for PFS in endometrial cancer, providing insights into the tumor microenvironment.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAcademic Press-
dc.relation.isPartOfGynecologic Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHB7-H1 Antigen/*biosynthesis/immunology-
dc.subject.MESHEndometrioid/*immunology Carcinoma-
dc.subject.MESHEndometrial Neoplasms/*immunology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProgrammed Cell Death 1 Receptor/*biosynthesis/immunology-
dc.subject.MESHRetrospective Studies-
dc.titlePrognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentYonsei Biomedical Research Center-
dc.contributor.googleauthorJisup Kim-
dc.contributor.googleauthorSinae Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorWookyeom Yang-
dc.contributor.googleauthorHanbyoul Cho-
dc.contributor.googleauthorDoo Byung Chay-
dc.contributor.googleauthorSeong Jin Cho-
dc.contributor.googleauthorSoonwon Hong-
dc.contributor.googleauthorJae-Hoon Kim-
dc.identifier.doi10.1016/j.ygyno.2018.02.013-
dc.contributor.localIdA04912-
dc.contributor.localIdA05313-
dc.contributor.localIdA00876-
dc.contributor.localIdA03312-
dc.contributor.localIdA03921-
dc.contributor.localIdA04015-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ00956-
dc.identifier.eissn1095-6859-
dc.identifier.pmid29572029-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S009082581830132X-
dc.subject.keywordEndometrial cancer-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordPrognostic factor-
dc.subject.keywordProgrammed cell death 1 ligand 1-
dc.subject.keywordTumor microenvironments-
dc.contributor.alternativeNameKim, Si Nae-
dc.contributor.alternativeNameKim, Jae Hoon-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameCho, Han Byoul-
dc.contributor.alternativeNameChay, Doo Byung-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorKim, Jisup-
dc.contributor.affiliatedAuthorKim, Si Nae-
dc.contributor.affiliatedAuthorKim, Jae Hoon-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorCho, Han Byoul-
dc.contributor.affiliatedAuthorChay, Doo Byung-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.citation.volume149-
dc.citation.number2-
dc.citation.startPage381-
dc.citation.endPage387-
dc.identifier.bibliographicCitationGynecologic Oncology, Vol.149(2) : 381-387, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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