Cited 34 times in
Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer
DC Field | Value | Language |
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dc.contributor.author | 김시내 | - |
dc.contributor.author | 김재훈 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 조한별 | - |
dc.contributor.author | 채두병 | - |
dc.contributor.author | 홍순원 | - |
dc.contributor.author | 김지섭 | - |
dc.date.accessioned | 2018-08-28T17:14:32Z | - |
dc.date.available | 2018-08-28T17:14:32Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162397 | - |
dc.description.abstract | OBJECTIVE: Monoclonal antibodies targeting programmed cell death-1 (PD-1)/programmed death ligand 1 (PD-L1) demonstrated promising clinical response. The predictive/prognostic value of PD-1/PD-L1 immunohistochemistry (IHC) has been evaluated in many cancer types. However, the prognostic value of PD-1/PD-L1 IHC has not been evaluated in endometrial cancer. METHODS: We conducted a retrospective study to quantify the IHC CD8, PD-1, and PD-L1 expressions in immune cells at center of tumor (CT), invasive margin (IM), and/or tumor cell in 183 primary endometrial cancer samples from a single cohort, followed by their reciprocal combinations, including compartmental differences, and correlated them with overall survival (OS) and progression-free survival (PFS). RESULTS: In repeated Cox multivariable models adjusted by clinicoimmunopathologic factors, high CT-PD-L1 was an independent adverse prognostic factor for PFS in all patients and in the microsatellite-stable subgroup. Immune marker ratios revealed independently shorter PFS for high CT-PD-L1/CT-CD8 and CT-PD-L1/CT-PD-1 ratios. Classification of endometrial cancer into four groups based on CT-CD8 and CT-PD-L1 revealed significantly different survival among groups. CONCLUSIONS: The high PD-L1/CD8 ratio and the high expression of PD-L1 on immune cells were independent poor prognostic factors for PFS in endometrial cancer, providing insights into the tumor microenvironment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | B7-H1 Antigen/*biosynthesis/immunology | - |
dc.subject.MESH | Endometrioid/*immunology Carcinoma | - |
dc.subject.MESH | Endometrial Neoplasms/*immunology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Programmed Cell Death 1 Receptor/*biosynthesis/immunology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Yonsei Biomedical Research Center | - |
dc.contributor.googleauthor | Jisup Kim | - |
dc.contributor.googleauthor | Sinae Kim | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Wookyeom Yang | - |
dc.contributor.googleauthor | Hanbyoul Cho | - |
dc.contributor.googleauthor | Doo Byung Chay | - |
dc.contributor.googleauthor | Seong Jin Cho | - |
dc.contributor.googleauthor | Soonwon Hong | - |
dc.contributor.googleauthor | Jae-Hoon Kim | - |
dc.identifier.doi | 10.1016/j.ygyno.2018.02.013 | - |
dc.contributor.localId | A04912 | - |
dc.contributor.localId | A05313 | - |
dc.contributor.localId | A00876 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A03921 | - |
dc.contributor.localId | A04015 | - |
dc.contributor.localId | A04411 | - |
dc.relation.journalcode | J00956 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.identifier.pmid | 29572029 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S009082581830132X | - |
dc.subject.keyword | Endometrial cancer | - |
dc.subject.keyword | Immunohistochemistry | - |
dc.subject.keyword | Prognostic factor | - |
dc.subject.keyword | Programmed cell death 1 ligand 1 | - |
dc.subject.keyword | Tumor microenvironments | - |
dc.contributor.alternativeName | Kim, Si Nae | - |
dc.contributor.alternativeName | Kim, Jae Hoon | - |
dc.contributor.alternativeName | Lee, Hye Sun | - |
dc.contributor.alternativeName | Cho, Han Byoul | - |
dc.contributor.alternativeName | Chay, Doo Byung | - |
dc.contributor.alternativeName | Hong, Soon Won | - |
dc.contributor.affiliatedAuthor | Kim, Jisup | - |
dc.contributor.affiliatedAuthor | Kim, Si Nae | - |
dc.contributor.affiliatedAuthor | Kim, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Hye Sun | - |
dc.contributor.affiliatedAuthor | Cho, Han Byoul | - |
dc.contributor.affiliatedAuthor | Chay, Doo Byung | - |
dc.contributor.affiliatedAuthor | Hong, Soon Won | - |
dc.citation.volume | 149 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 381 | - |
dc.citation.endPage | 387 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, Vol.149(2) : 381-387, 2018 | - |
dc.identifier.rimsid | 59981 | - |
dc.type.rims | ART | - |
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