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Apparent diffusion coefficient of hepatocellular carcinoma on diffusion-weighted imaging: Histopathologic tumor grade versus arterial vascularity during dynamic magnetic resonance imaging

Authors
 In Kyung Park  ;  Jeong-Sik Yu  ;  Eun-Suk Cho  ;  Joo Hee Kim  ;  Jae-Joon Chung 
Citation
 PLoS One, Vol.13(5) : e0197070, 2018 
Journal Title
 PLoS One 
Issue Date
2018
Abstract
OBJECTIVES: Apparent diffusion coefficient (ADC) has been suggested to reflect the tumor grades of hepatocellular carcinomas (HCCs); i.e., it can be used as a biomarker to predict the patients' prognosis. To verify its feasibility as a biomarker, the present study sought to determine how the ADC values of HCC are affected by a tumor's histopathologic grade and arterial vascularity. MATERIALS AND METHODS: From 131 consecutive patients, 141 surgically resected HCCs (16 well-differentiated [wd-HCCs], 83 moderately-differentiated [md-HCCs], and 42 poorly-differentiated HCCs [pd-HCCs]) were subjected to a comparison of the tumors' arterial vascularity (non-, slightly-, or markedly-hypervascular) determined on dynamic magnetic resonance imaging (MRI) and the ADC was measured retrospectively. RESULTS: The pd-HCCs (1.05+/-0.16 x 10-3 mm2/s) had a significantly lower ADC than md-HCCs (1.16+/-0.21 x 10-3 mm2/s; p = 0.010), but there was no significant difference compared to wd-HCCs (1.11+/-0.18 x 10-3 mm2/s; p = 0.968). The mean ADC was significantly higher in markedly hypervascular lesions (1.20+/-0.20 x 10-3 mm2/s) than in nonhypervascular lesions (0.95+/-0.14 x 10-3mm2/s; p<0.001) or slightly hypervascular lesions (1.04+/-0.15 x 10-3mm2/s; p<0.001). The ADC values and arterial vascularity were significantly correlated in wd-HCCs (p = 0.005) and md-HCCs (p<0.001). The mean ADC of pd-HCCs was significantly lower than those of other lesions, even in the markedly hypervascular lesion subgroup (p = 0.020). CONCLUSION: Although pd-HCC constantly shows low ADCs regardless of arterial vascularities, ADCs cannot stably stratify histopathologic tumor grades due to the variable features of wd-HCCs; and the ADC should be used with caution as a tumor biomarker of HCC.
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DOI
10.1371/journal.pone.0197070
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김주희(Kim, Joo Hee) ORCID logo https://orcid.org/0000-0001-5383-3602
박인경(Park, In Kyung)
유정식(Yu, Jeong Sik) ORCID logo https://orcid.org/0000-0002-8171-5838
정재준(Chung, Jae Joon) ORCID logo https://orcid.org/0000-0002-7447-1193
조은석(Cho, Eun Suk)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162373
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