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Apparent diffusion coefficient of hepatocellular carcinoma on diffusion-weighted imaging: Histopathologic tumor grade versus arterial vascularity during dynamic magnetic resonance imaging
DC Field | Value | Language |
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dc.contributor.author | 김주희 | - |
dc.contributor.author | 유정식 | - |
dc.contributor.author | 정재준 | - |
dc.contributor.author | 조은석 | - |
dc.date.accessioned | 2018-08-28T17:12:48Z | - |
dc.date.available | 2018-08-28T17:12:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/162373 | - |
dc.description.abstract | OBJECTIVES: Apparent diffusion coefficient (ADC) has been suggested to reflect the tumor grades of hepatocellular carcinomas (HCCs); i.e., it can be used as a biomarker to predict the patients' prognosis. To verify its feasibility as a biomarker, the present study sought to determine how the ADC values of HCC are affected by a tumor's histopathologic grade and arterial vascularity. MATERIALS AND METHODS: From 131 consecutive patients, 141 surgically resected HCCs (16 well-differentiated [wd-HCCs], 83 moderately-differentiated [md-HCCs], and 42 poorly-differentiated HCCs [pd-HCCs]) were subjected to a comparison of the tumors' arterial vascularity (non-, slightly-, or markedly-hypervascular) determined on dynamic magnetic resonance imaging (MRI) and the ADC was measured retrospectively. RESULTS: The pd-HCCs (1.05+/-0.16 x 10-3 mm2/s) had a significantly lower ADC than md-HCCs (1.16+/-0.21 x 10-3 mm2/s; p = 0.010), but there was no significant difference compared to wd-HCCs (1.11+/-0.18 x 10-3 mm2/s; p = 0.968). The mean ADC was significantly higher in markedly hypervascular lesions (1.20+/-0.20 x 10-3 mm2/s) than in nonhypervascular lesions (0.95+/-0.14 x 10-3mm2/s; p<0.001) or slightly hypervascular lesions (1.04+/-0.15 x 10-3mm2/s; p<0.001). The ADC values and arterial vascularity were significantly correlated in wd-HCCs (p = 0.005) and md-HCCs (p<0.001). The mean ADC of pd-HCCs was significantly lower than those of other lesions, even in the markedly hypervascular lesion subgroup (p = 0.020). CONCLUSION: Although pd-HCC constantly shows low ADCs regardless of arterial vascularities, ADCs cannot stably stratify histopathologic tumor grades due to the variable features of wd-HCCs; and the ADC should be used with caution as a tumor biomarker of HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Apparent diffusion coefficient of hepatocellular carcinoma on diffusion-weighted imaging: Histopathologic tumor grade versus arterial vascularity during dynamic magnetic resonance imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | In Kyung Park | - |
dc.contributor.googleauthor | Jeong-Sik Yu | - |
dc.contributor.googleauthor | Eun-Suk Cho | - |
dc.contributor.googleauthor | Joo Hee Kim | - |
dc.contributor.googleauthor | Jae-Joon Chung | - |
dc.identifier.doi | 10.1371/journal.pone.0197070 | - |
dc.contributor.localId | A00951 | - |
dc.contributor.localId | A02500 | - |
dc.contributor.localId | A03712 | - |
dc.contributor.localId | A03881 | - |
dc.contributor.localId | A05625 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 29750794 | - |
dc.contributor.alternativeName | Kim, Joo Hee | - |
dc.contributor.alternativeName | Yu, Jeong Sik | - |
dc.contributor.alternativeName | Chung, Jae Joon | - |
dc.contributor.alternativeName | Cho, Eun Suk | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hee | - |
dc.contributor.affiliatedAuthor | Yu, Jeong Sik | - |
dc.contributor.affiliatedAuthor | Chung, Jae Joon | - |
dc.contributor.affiliatedAuthor | Cho, Eun Suk | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e0197070 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.13(5) : e0197070, 2018 | - |
dc.identifier.rimsid | 59957 | - |
dc.type.rims | ART | - |
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