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Efficacy of adjuvant chemotherapy for completely resected stage IB non-small cell lung cancer: a retrospective study

Authors
 Hye Jung Park  ;  Heae Surng Park  ;  Yoon Jin Cha  ;  Sungsoo Lee  ;  Hei-Cheul Jeung  ;  Jae Yong Cho  ;  Hyung Jung Kim  ;  Min Kwang Byun 
Citation
 Journal of Thoracic Disease, Vol.10(4) : 2279-2287, 2018 
Journal Title
 Journal of Thoracic Disease 
ISSN
 2072-1439 
Issue Date
2018
Keywords
Lung cancer ; adjuvant chemotherapy ; early stage
Abstract
Background: Lung cancer is being increasingly detected in the early stages, highlighting the importance of lung cancer screening. However, there is no consensus on the post-operative management of stage IB non-small cell lung cancer (NSCLC). Therefore, this study aimed to identify the predictive factors for prognosis of stage IB NSCLC and determine the efficacy of adjuvant chemotherapy on recurrence and survival. Methods: We enrolled 89 patients with stage IB NSCLC who underwent complete resection surgery at Gangnam Severance Hospital from Jan 2008 to Dec 2014. As per the National Comprehensive Cancer Network guidelines, patients were considered to be at high risk when they showed poorly differentiated tumors, lymphovascular invasion, tumor size >4 cm, and visceral pleural invasion (VPI). Results: Among the 89 patients, 27 underwent adjuvant chemotherapy. Young patients or patients with squamous cell lung cancer received adjuvant chemotherapy frequently. Adjuvant chemotherapy was not a significant factor for disease-free survival and overall survival. Adjuvant chemotherapy did not show a significant protective effect for survival, even for high-risk patients. However, VPI was a significant risk factor for disease-free survival [hazard ratio (HR): 7.051; 95% confidence interval (CI): 1.570-31.659; P=0.011] and overall survival (HR: 8.289; 95% CI: 1.036-66.307; P=0.046), even after adjustment for various factors. Conclusions: Adjuvant chemotherapy does not affect the prognosis of stage IB NSCLC, even in high-risk patients. Additionally, VPI is a strong prognostic factor of stage IB NSCLC.
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DOI
10.21037/jtd.2018.03.184
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)
Yonsei Authors
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
박혜성(Park, Heae Surng)
박혜정(Park, Hye Jung) ORCID logo https://orcid.org/0000-0002-1862-1003
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
이성수(Lee, Sung Soo) ORCID logo https://orcid.org/0000-0001-8998-9510
정희철(Jeung, Hei Cheul)
조재용(Cho, Jae Yong) ORCID logo https://orcid.org/0000-0002-0926-1819
차윤진(Cha, Yoon Jin) ORCID logo https://orcid.org/0000-0002-5967-4064
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162371
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