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Disturbed retrieval network and prospective memory decline in postpartum women

Authors
 Na-Young Shin  ;  Yunjin Bak  ;  Yoonjin Nah  ;  Sanghoon Han  ;  Dong Joon Kim  ;  Se Joo Kim  ;  Jong Eun Lee  ;  Sang-Guk Lee  ;  Seung-Koo Lee 
Citation
 Scientific Reports, Vol.8(1) : 5476, 2018 
Journal Title
 Scientific Reports 
Issue Date
2018
Abstract
Prospective memory (PM) refers to the ability to remember to execute an intended action in the future. For successful PM performance, both top-down strategic monitoring and bottom-up spontaneous retrieval processes need to be appropriately recruited. We assessed PM performance and used fMRI to discover relevant neural correlates and possible predictors for PM performance in 25 postpartum and 26 nulliparous age- and education-matched women. Postpartum women showed decreased PM performance, a higher number of nocturnal awakenings, and lower estradiol level. The postpartum women had decreased functional connectivity (FC) in the right hippocampus and ventral frontoparietal networks (FPN) during retrieval-dominant PM trials relative to maintenance-dominant ongoing trials in the PM block. On multivariate analyses, decreased FC between the right hippocampus and ventral FPN and a higher number of nocturnal awakenings were independent predictors for poor PM performance after adjusting for age, education, estradiol level, and depressive symptoms. On mediation analyses, the estradiol level was found to have an indirect effect on PM accuracy via altered FC as a mediator. This suggests that decreased FC within the spontaneous retrieval-related regions including the right hippocampus and ventral FPN, disrupted sleep rhythms, and decreased estradiol level may contribute to poor PM performance in postpartum women.
Files in This Item:
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DOI
10.1038/s41598-018-23875-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실)
Yonsei Authors
김동준(Kim, Dong Joon) ORCID logo https://orcid.org/0000-0002-7035-087X
김세주(Kim, Se Joo) ORCID logo https://orcid.org/0000-0002-5438-8210
이상국(Lee, Sang-Guk) ORCID logo https://orcid.org/0000-0003-3862-3660
이승구(Lee, Seung Koo) ORCID logo https://orcid.org/0000-0001-5646-4072
이종은(Lee, Jong Eun) ORCID logo https://orcid.org/0000-0001-6203-7413
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162166
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