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A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin

Authors
 Hye Jung Park  ;  Kyung Soo Suk  ;  Jung Won Park 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.10(2) : 184-186, 2018 
Journal Title
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
ISSN
 2092-7355 
Issue Date
2018
Abstract
Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. After 30 minutes, the patient developed anaphylactic shock with systemic skin rash and angioedema. Repeated intravenous bolus and infusion of vasopressor were carried out, and her blood pressure normalized. Skin test and specific immunoglobulin E test showed positive results for bovine thrombin and beef, respectively. During the second stage of operation (After 10 days from first stage of operation), bovine-derived thrombin powder was excluded and the operation was successful without any unexpected events. Therefore, bovine thrombin should be used with caution because it might cause anaphylaxis.
Files in This Item:
T201800580.pdf Download
DOI
10.4168/aair.2018.10.2.184
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jung Won(박정원)
Park, Hye Jung(박혜정) ORCID logo https://orcid.org/0000-0002-1862-1003
Suk, Kyung Soo(석경수) ORCID logo https://orcid.org/0000-0003-0633-2658
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162079
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