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Investigation on the Cutaneous Change Induced by Face-Lifting Monodirectional Barbed Polydioxanone Thread

Authors
 Kim, Jihee  ;  Zheng, Zhenlong  ;  Kim, Heesu  ;  Nam, Kyung Ae  ;  Chung, Kee Yang 
Citation
 DERMATOLOGIC SURGERY, Vol.43(1) : 74-80, 2017 
Journal Title
 DERMATOLOGIC SURGERY 
ISSN
 1076-0512 
Issue Date
2017
MeSH
Absorbable Implants ; Animals ; Collagen Type I/genetics ; Collagen Type I/metabolism* ; Equipment Design ; Foreign-Body Reaction/etiology ; Foreign-Body Reaction/pathology* ; Guinea Pigs ; Polydioxanone*/adverse effects ; RNA, Messenger/metabolism ; Rhytidoplasty/instrumentation ; Skin/metabolism* ; Skin/pathology* ; Sutures*/adverse effects ; Time Factors ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism*
Abstract
BACKGROUND: Owing to its potentially greater mechanical force on the implanted tissue, barbed thread is frequently used in face-lifting procedures. However, the long-term durability thereof remains controversial. Moreover, reports on underlying histologic and molecular changes resulting from face-lifting procedures are scarce. OBJECTIVE: To evaluate histologic and molecular changes induced by absorbable, barbed face-lifting thread in an animal model. MATERIALS AND METHODS: Fragments of monofilament, monodirectionally barbed polydioxanone thread were implanted in dorsal skin from 12 guinea pigs. Tissue samples were harvested at 1, 3, and 7 months thereafter. Histopathologic analysis and quantification of Type 1 collagen and transforming growth factor beta 1 (TGF-β1) levels were performed. RESULTS: Implantation of a single fragment induced fibrous capsule around the thread. Tissue reactions were strongest at 1 month after implantation, showing marked infiltration of inflammatory cells and fibroblasts, which gradually decreased. On molecular analysis, Type 1 collagen and TGF-β1 levels were significantly increased, compared to normal skin, throughout the 7-month study period. CONCLUSION: Our results suggest that implantation of barbed thread induces strong anchorage to skin tissue. Quantitative analysis of collagen and its downstream signaling molecule TGF-β supports the long-term durability of the thread. Therefore, the authors expect potential beneficial effect for rejuvenation on its clinical application.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042728-201701000-00011&LSLINK=80&D=ovft
DOI
10.1097/DSS.0000000000000925
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Nam, Kyoung Ae(남경애)
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
Zheng, Zhen Long(정진룡)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161423
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