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Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants

 Yoon Hee Kim  ;  Hyun Joo Shin  ;  In Suk Sol  ;  Soo Yeon Kim  ;  Jong Deok Kim  ;  Haesung Yoon  ;  Kyung Won Kim  ;  Myung-Joon Kim  ;  Mi-Jung Lee  ;  Myung Hyun Sohn 
 Scientific Reports, Vol.7(1) : 15128, 2017 
Journal Title
 Scientific Reports 
Issue Date
Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infants (mean age, 10.9 ± 6.3 months) diagnosed with post-infectious BO between 2009 and 2016. All subjects underwent multiple breath washout tests. For quantitative analysis of chest CT, the mean lung area attenuation value was used as an individual cutoff to determine the air-trapping lung volume. The mean cutoff lung attenuation value was -659 Hounsfield units, the mean total lung volume was 265 ml, and the mean air-trapping lung volume percentage was 22.9%. Functional residual capacity correlated with total lung volume and normal attenuation lung volume (p < 0.02). LCI (p < 0.02) and moment ratio (MR) 1 (p < 0.05) correlated with the air-trapping lung volume percentage. The concordance indices of LCI (0.659, p = 0.025) and MR1 (0.642, p = 0.046) were significantly correlated with the air-trapping lung volume percentage from CT. LCI and quantitative air-trapping lung volume from chest CT are feasible, complimentary tools for assessing infants with post-infectious BO.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김명준(Kim, Myung Joon) ORCID logo https://orcid.org/0000-0002-4608-0275
김수연(Kim, Soo Yeon) ORCID logo https://orcid.org/0000-0003-4965-6193
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
김종덕(Kim, Jong Deok)
설인숙(Sol, In Suk) ORCID logo https://orcid.org/0000-0003-2470-9682
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
신현주(Shin, Hyun Joo) ORCID logo https://orcid.org/0000-0002-7462-2609
윤혜성(Yoon, Haesung) ORCID logo https://orcid.org/0000-0003-0581-8656
이미정(Lee, Mi-Jung) ORCID logo https://orcid.org/0000-0003-3244-9171
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