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Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants

Authors
 Yoon Hee Kim  ;  Hyun Joo Shin  ;  In Suk Sol  ;  Soo Yeon Kim  ;  Jong Deok Kim  ;  Haesung Yoon  ;  Kyung Won Kim  ;  Myung-Joon Kim  ;  Mi-Jung Lee  ;  Myung Hyun Sohn 
Citation
 Scientific Reports, Vol.7(1) : 15128, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infants (mean age, 10.9 ± 6.3 months) diagnosed with post-infectious BO between 2009 and 2016. All subjects underwent multiple breath washout tests. For quantitative analysis of chest CT, the mean lung area attenuation value was used as an individual cutoff to determine the air-trapping lung volume. The mean cutoff lung attenuation value was -659 Hounsfield units, the mean total lung volume was 265 ml, and the mean air-trapping lung volume percentage was 22.9%. Functional residual capacity correlated with total lung volume and normal attenuation lung volume (p < 0.02). LCI (p < 0.02) and moment ratio (MR) 1 (p < 0.05) correlated with the air-trapping lung volume percentage. The concordance indices of LCI (0.659, p = 0.025) and MR1 (0.642, p = 0.046) were significantly correlated with the air-trapping lung volume percentage from CT. LCI and quantitative air-trapping lung volume from chest CT are feasible, complimentary tools for assessing infants with post-infectious BO.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161348
DOI
10.1038/s41598-017-15330-8
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ; 김명준(Kim, Myung Joon) ; 김수연(Kim, Soo Yeon) ; 김윤희(Kim, Yoon Hee) ; 김종덕(Kim, Jong Deok) ; 설인숙(Sol, In Suk) ; 손명현(Sohn, Myung Hyun) ; 신현주(Shin, Hyun Joo) ; 윤혜성(Yoon, Haesung) ; 이미정(Lee, Mi Jung)
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