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Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants

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dc.contributor.author김경원-
dc.contributor.author김명준-
dc.contributor.author김수연-
dc.contributor.author김윤희-
dc.contributor.author김종덕-
dc.contributor.author설인숙-
dc.contributor.author손명현-
dc.contributor.author신현주-
dc.contributor.author윤혜성-
dc.contributor.author이미정-
dc.date.accessioned2018-07-20T08:39:37Z-
dc.date.available2018-07-20T08:39:37Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161348-
dc.description.abstractPost-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infants (mean age, 10.9 ± 6.3 months) diagnosed with post-infectious BO between 2009 and 2016. All subjects underwent multiple breath washout tests. For quantitative analysis of chest CT, the mean lung area attenuation value was used as an individual cutoff to determine the air-trapping lung volume. The mean cutoff lung attenuation value was -659 Hounsfield units, the mean total lung volume was 265 ml, and the mean air-trapping lung volume percentage was 22.9%. Functional residual capacity correlated with total lung volume and normal attenuation lung volume (p < 0.02). LCI (p < 0.02) and moment ratio (MR) 1 (p < 0.05) correlated with the air-trapping lung volume percentage. The concordance indices of LCI (0.659, p = 0.025) and MR1 (0.642, p = 0.046) were significantly correlated with the air-trapping lung volume percentage from CT. LCI and quantitative air-trapping lung volume from chest CT are feasible, complimentary tools for assessing infants with post-infectious BO.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleLung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorYoon Hee Kim-
dc.contributor.googleauthorHyun Joo Shin-
dc.contributor.googleauthorIn Suk Sol-
dc.contributor.googleauthorSoo Yeon Kim-
dc.contributor.googleauthorJong Deok Kim-
dc.contributor.googleauthorHaesung Yoon-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorMyung-Joon Kim-
dc.contributor.googleauthorMi-Jung Lee-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.identifier.doi10.1038/s41598-017-15330-8-
dc.contributor.localIdA00303-
dc.contributor.localIdA00425-
dc.contributor.localIdA04724-
dc.contributor.localIdA00799-
dc.contributor.localIdA05318-
dc.contributor.localIdA01941-
dc.contributor.localIdA01967-
dc.contributor.localIdA02178-
dc.contributor.localIdA04989-
dc.contributor.localIdA02774-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid29123150-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.alternativeNameKim, Myung Joon-
dc.contributor.alternativeNameKim, Soo Yeon-
dc.contributor.alternativeNameKim, Yoon Hee-
dc.contributor.alternativeNameKim, Jong Deok-
dc.contributor.alternativeNameSol, In Suk-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameShin, Hyun Joo-
dc.contributor.alternativeNameYoon, Haesung-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.contributor.affiliatedAuthorKim, Myung Joon-
dc.contributor.affiliatedAuthorKim, Soo Yeon-
dc.contributor.affiliatedAuthorKim, Yoon Hee-
dc.contributor.affiliatedAuthorKim, Jong Deok-
dc.contributor.affiliatedAuthorSol, In Suk-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.contributor.affiliatedAuthorShin, Hyun Joo-
dc.contributor.affiliatedAuthorYoon, Haesung-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage15128-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.7(1) : 15128, 2017-
dc.identifier.rimsid61267-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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